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NUMB gene

Known as: Numb Homolog (Drosophila) Gene, NUMB, numb homolog (Drosophila) 
This gene plays a role in neurogenesis.
National Institutes of Health

Related topics

Related topics

3 relations
NeurogenesisProtein Numb HomologSignal Transduction

Papers overview

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Highly Cited
2014
Highly Cited
2014
The RNA‐Binding Protein Musashi‐1 Regulates Proteasome Subunit Expression in Breast Cancer‐ and Glioma‐Initiating Cells
Cancer stem cells (CSCs) or tumor‐initiating cells, similar to normal tissue stem cells, rely on developmental pathways, such as… 
Highly Cited
2010
Highly Cited
2010
Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain
Numb can antagonize Notch signaling to diversify the fates of sister cells. We report here that paired sister cells acquire… 
2008
2008
Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
The Mdm2 oncoprotein is an E3 ubiquitin ligase required to maintain the p53 protein at low levels in embryonic and adult tissues… 
Highly Cited
2003
Highly Cited
2003
The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila
Apoptosis is prevalent during development of the central nervous system (CNS), yet very little is known about the signals that… 
2002
2002
Numb modifies neuronal vulnerability to amyloid β-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis
Increased production of neurotoxic forms of amyloid β-peptide (Aβ) and abnormalities in neuronal calcium homeostasis play central… 
2002
2002
Plane of Cell Cleavage and Numb Distribution during Cell Division Relative to Cell Differentiation in the Developing Retina
Progenitor cells in the early developing nervous system can divide symmetrically, giving rise to two daughter cells that divide… 
Highly Cited
1999
Highly Cited
1999
Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch.
Specification of cell fate in the adult sensory organs is known to be dependent on intrinsic and extrinsic signals. We show that… 
Highly Cited
1999
Highly Cited
1999
Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS.
Cell intrinsic and cell extrinsic factors mediate asymmetric cell divisions during neurogenesis in the Drosophila embryo. In the… 
1999
1999
Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system
Highly Cited
1997
Highly Cited
1997
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.
In Drosophila, an adult external sensory organ (bristle) consists of four distinct cells which arise from a sensory organ… 
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