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Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.
Adult Drosophila possess a large number of sensory organs, including large and small bristles and other types of sensilla, each arising from a single mother cell at particular positions in a… Expand
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
- H. Ikeshima-Kataoka, J. Skeath, Y. Nabeshima, C. Doe, F. Matsuzaki
- Medicine, Biology
- 11 December 1997
Asymmetric cell division is a general process used in many developmental contexts to create two differently fated cells from a single progenitor cell. Intrinsic mechanisms like the asymmetric… Expand
Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway
- M. D. Thakur, Yunfeng Feng, R. Jagannathan, Midori J. Seppa, J. Skeath, G. Longmore
- Medicine, Biology
- Current Biology
- 13 April 2010
The mammalian Ajuba LIM proteins (Ajuba, LIMD1, and WTIP) are adaptor proteins that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia. Determining… Expand
Drosophila Homeodomain Protein dHb9 Directs Neuronal Fate via Crossrepressive and Cell-Nonautonomous Mechanisms
Here we present the identification and characterization of dHb9, the Drosophila homolog of vertebrate Hb9, which encodes a factor central to motorneuron (MN) development. We show that dHb9 regulates… Expand
heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.
After invagination of the mesodermal primordium in the gastrulating Drosophila embryo, the internalized cells migrate in a dorsolateral direction along the overlying ectoderm. This movement generates… Expand
Genetic control of Drosophila nerve cord development
The Drosophila ventral nerve cord has been a central model system for studying the molecular genetic mechanisms that control CNS development. Studies show that the generation of neural diversity is a… Expand
Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS.
In Drosophila, most neuronal siblings have different fates ('A/B'). Here we demonstrate that mutations in sanpodo, a tropomodulin actin-binding protein homologue, equalize a diverse array of sibling… Expand
Drosophila Lame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development.
A hallmark of mature skeletal muscles is the presence of multinucleate muscle fibers. In Drosophila, the formation of muscle syncytia requires the cooperative participation of two types of myoblasts,… Expand
Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.
Drosophila possesses two FGF receptors which are encoded by the heartless and breathless genes. HEARTLESS is essential for early migration and patterning of the embryonic mesoderm, while BREATHLESS… Expand
Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis
The regulatory networks acting in individual neurons to control their stereotyped differentiation, connectivity, and function are not well understood. Here, we demonstrate that homeodomain protein… Expand