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Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis
A global double‐fluorescent Cre reporter mouse
The Cre/loxP system has been used extensively for conditional mutagenesis in mice. Reporters of Cre activity are important for defining the spatial and temporal extent of Cre‐mediated recombination.…
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast.
The cellular organization of mushroom bodies and the development of different MB neurons at the single cell level is illustrated to allow for future studies on the molecular mechanisms of mushroom body development.
RHO GTPASES in neuronal morphogenesis
- L. Luo
- BiologyNature Reviews Neuroscience
- 1 December 2000
The Rho family of small GTPases act as intracellular molecular switches that transduce signals from extracellular stimuli to the actin cytoskeleton and the nucleus, underscoring their importance in the development and function of the nervous system.
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation
Diversity and Wiring Variability of Olfactory Local Interneurons in the Drosophila Antennal Lobe
- Ya-Hui Chou, M. Spletter, E. Yaksi, J. C. Leong, Rachel I. Wilson, L. Luo
- BiologyNature Neuroscience
- 15 January 2010
A comprehensive genetic, anatomical and electrophysiological analysis of local interneurons in the Drosophila melanogaster antennal lobe reveals an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Dosophila connectome.
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity.
- L. Luo
- BiologyAnnual review of cell and developmental biology
Evidence is presented that signaling pathways involving the Rho family of small GTPases are key regulators of actin polymerization and myosin function in the context of different aspects of neuronal morphogenesis.