• Publications
  • Influence
Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis
TLDR
A genetic mosaic system in Drosophila is described, in which a dominant repressor of a cell marker is placed in trans to a mutant gene of interest, which allows for the study of gene functions in neuroblast proliferation, axon guidance, and dendritic elaboration in the complex central nervous system. Expand
A global double‐fluorescent Cre reporter mouse
The Cre/loxP system has been used extensively for conditional mutagenesis in mice. Reporters of Cre activity are important for defining the spatial and temporal extent of Cre‐mediated recombination.Expand
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
TLDR
Using this new mosaic system, not only can normal brain development be described with unprecedented single cell resolution, but also the underlying molecular mechanisms can be investigated by identifying genes that are required for these developmental processes. Expand
Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast.
TLDR
The cellular organization of mushroom bodies and the development of different MB neurons at the single cell level is illustrated to allow for future studies on the molecular mechanisms of mushroom body development. Expand
RHO GTPASES in neuronal morphogenesis
  • L. Luo
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 1 December 2000
TLDR
The Rho family of small GTPases act as intracellular molecular switches that transduce signals from extracellular stimuli to the actin cytoskeleton and the nucleus, underscoring their importance in the development and function of the nervous system. Expand
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping
TLDR
The utility of viral-genetic tracing strategies to elucidate the complex neural substrates that underlie motivated behaviors is highlighted, including a previously unappreciated top-down reinforcing circuit from anterior cortex to lateral nucleus accumbens via VTA-DA neurons. Expand
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation
TLDR
High-resolution, quantitative maps of the MB and LH for 35 input PN channels and several groups of LH neurons are created to suggest that the LH is organized according to biological values of olfactory input. Expand
Rac function and regulation during Drosophila development
TLDR
The three Drosophila Rac genes, Rac1, Rac2 and Mtl, have overlapping functions in the control of epithelial morphogenesis, myoblast fusion, and axon growth and guidance and are not required for the establishment of planar cell polarity, as had been suggested on the basis of studies using dominant mutant isoforms. Expand
Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton
TLDR
Drosophila Rho-associated kinase (Drok) works downstream of Fz/Dsh to mediate a branch of the planar polarity pathway involved in ommatidial rotation in the eye and in restricting actin bundle formation to a single site in developing wing cells. Expand
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity.
  • L. Luo
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 2002
TLDR
Evidence is presented that signaling pathways involving the Rho family of small GTPases are key regulators of actin polymerization and myosin function in the context of different aspects of neuronal morphogenesis. Expand
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