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NOTCH2 protein, human

Known as: Notch homolog 2 (Drosophila) protein, human, notch-2 protein, human, Notch 2 
Neurogenic locus notch homolog protein 2 (2471 aa, ~265 kDa) is encoded by the human NOTCH2 gene. This protein plays a role in intercellular… 
National Institutes of Health

Related topics

Related topics

18 relations
Ankyrin RepeatCell Fate ControlCellular MembraneEGF-Like Domain

Broader (1)

Receptor, Notch2

Papers overview

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Highly Cited
2007
Highly Cited
2007
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
The Notch pathway regulates cell fate determination in numerous developmental processes. Here we report that Notch2 acts non… 
Highly Cited
2005
Highly Cited
2005
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration.
BACKGROUND & AIMS The mammalian pancreas has a strong regenerative potential, but the origin of organ restoration is not clear… 
Highly Cited
2003
Highly Cited
2003
Phosphorylation by Glycogen Synthase Kinase-3β Down-regulates Notch Activity, a Link for Notch and Wnt Pathways*
Phosphorylation of Notch proteins has been indirectly correlated with Notch activation and nuclear translocation as well as… 
Highly Cited
2001
Highly Cited
2001
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
The role of Notch signaling in growth/differentiation control of mammalian epithelial cells is still poorly defined. We show that… 
Highly Cited
1999
Highly Cited
1999
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.
Notch family genes encode transmembrane proteins involved in cell-fate determination. Using gene targeting procedures, we… 
Highly Cited
1998
Highly Cited
1998
Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway
ABSTRACT E47 is a widely expressed transcription factor that activates B-cell-specific immunoglobulin gene transcription and is… 
Highly Cited
1996
Highly Cited
1996
Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development
Notch genes encode receptors for a signaling pathway that regulates neurogenesis. The DSL (Delta/Serrate/lag-2) genes encode… 
Highly Cited
1992
Highly Cited
1992
Notch2: a second mammalian Notch gene.
Notch is a cell surface receptor that mediates a wide variety of cellular interactions that specify cell fate during Drosophila… 
Highly Cited
1985
Highly Cited
1985
Molecular orbital predictions of the vibrational frequencies of some molecular ions.
Recent spectroscopic advances have led to the first determinations of infrared vibration-rotation bands of polyatomic molecular… 
Highly Cited
1982
Highly Cited
1982
Mechanism by which caffeine potentiates lethality of nitrogen mustard.
Caffeine is synergistic with many DNA-damaging agents in increasing lethality to mammalian cells. The mechanism is not well… 
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