NOTCH2 gene

Known as: notch 2, Notch 2 Gene, NOTCH, DROSOPHILA, HOMOLOG OF, 2 
This gene plays a role in cell-cell signaling.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Splenic marginal zone lymphoma (SMZL) is a B cell malignancy of unknown pathogenesis, and thus an orphan of targeted therapies… (More)
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Highly Cited
2011
Highly Cited
2011
We used an exome-sequencing strategy and identified an allelic series of NOTCH2 mutations in Hajdu-Cheney syndrome, an autosomal… (More)
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Highly Cited
2011
Highly Cited
2011
Hajdu-Cheney syndrome is a rare autosomal dominant skeletal disorder with facial anomalies, osteoporosis and acro-osteolysis. We… (More)
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Highly Cited
2006
Highly Cited
2006
Alagille syndrome (AGS) is caused by mutations in the gene for the Notch signaling pathway ligand Jagged1 (JAG1), which are found… (More)
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Highly Cited
2004
Highly Cited
2004
The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some neoplasms, and a tumor suppressor in… (More)
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Highly Cited
2003
Highly Cited
2003
The Notch genes play a key role in cellular differentiation. The significance of Notch1 during thymocyte development is well… (More)
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Highly Cited
2000
Highly Cited
2000
Proteins encoded by the fringe family of genes are required to modulate Notch signalling in a wide range of developmental… (More)
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Highly Cited
1999
Highly Cited
1999
Notch family genes encode transmembrane proteins involved in cell-fate determination. Using gene targeting procedures, we… (More)
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Highly Cited
1998
Highly Cited
1998
We have compared the ability of two mammalian Notch homologs, mouse Notchl and Notch2, to inhibit the granulocytic… (More)
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Highly Cited
1992
Highly Cited
1992
Notch is a cell surface receptor that mediates a wide variety of cellular interactions that specify cell fate during Drosophila… (More)
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