Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived from that of the human c-myc gene product, and all six antibodies recognize immunoblotted p62c- myc.
Targeted expression of MYCN causes neuroblastoma in transgenic mice
- W. Weiss, Ken Aldape, G. Mohapatra, B. Feuerstein, J. Bishop
- Medicine, BiologyEMBO Journal
- 1 June 1997
It is shown that increases in MYCN dosage or deficiencies in either of the tumor suppressor genes NF1 or RB1 can augment tumorigenesis by the transgene, and the genetic events involved in the genesis of neuroblastoma can be tumorigenic in more than one chronological sequence.
Senescence of human fibroblasts induced by oncogenic Raf.
- J. Zhu, D. Woods, M. McMahon, J. Bishop
- BiologyGenes & Development
- 1 October 1998
It is concluded that the kinase cascade initiated by Raf can regulate the expression of p16(Ink4a) and the proliferative arrest and senescence that follows and may provide a defense against neoplastic transformation when the MAP kinase signaling cascade is inappropriately active.
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
- A. Trumpp, M. Depew, J. Rubenstein, J. Bishop, G. Martin
- BiologyGenes & Development
- 1 December 1999
Genetic evidence is obtained that FGF8 has a dual function in BA1: it promotes mesenchymal cell survival and induces a developmental program required for BA1 morphogenesis, and the data suggest that the BA1 primordium is specified into a large proximal region that is controlled by F GF8, and a small distal region that depends on other signaling molecules for its outgrowth and patterning.
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
- M. Schwab, K. Alitalo, J. Trent
- BiologyNature
- 1 December 1983
It is shown here that a DNA domain detectable by partial homology to the myc oncogene is amplified up to 140-fold in cell lines derived from different human neuroblastomas and in a neuroblastoma tumour, but not in other tumour cells showing cytological evidence for gene amplification.
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
- D. Robbins, Kent E Nybakken, R. Kobayashi, J. Sisson, J. Bishop, P. Thérond
- BiologyCell
- 25 July 1997
Reversible tumorigenesis by MYC in hematopoietic lineages.
- D. Felsher, J. Bishop
- Biology, MedicineMolecules and Cells
- 1 August 1999
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
- D. Stéhelin, H. Varmus, J. Bishop, P. Vogt
- BiologyNature
- 11 March 1976
It is demonstrated here that the DNA of normal chicken cells contains nucleotide sequences closely related to at least a portion of the transforming gene(s) of ASV; in addition, similar sequences are widely distributed among DNA of avian species and that they have diverged roughly according to phylogenetic distances among the species.
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
- C. Shachaf, Andrew M. Kopelman, D. Felsher
- Biology, MedicineNature
- 28 October 2004
It is reported that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers and how oncogenic inactivation may reverse tumorigenesis in the most clinically difficult cancers is shown.
A nucleoprotein complex mediates the integration of retroviral DNA.
- B. Bowerman, P. Brown, J. Bishop, H. Varmus
- BiologyGenes & Development
- 1 April 1989
Analysis of the native state of viral DNA in cells acutely infected by murine leukemia virus shows that the viral capsid protein is part of the active nucleoprotein complex, but recognition of the complex by only a subset of anti-capsid sera implies that the protein is constrained conformationally.
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