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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived from that of the human c-myc gene product, and all six antibodies recognize immunoblotted p62c- myc. Expand
Targeted expression of MYCN causes neuroblastoma in transgenic mice
It is shown that increases in MYCN dosage or deficiencies in either of the tumor suppressor genes NF1 or RB1 can augment tumorigenesis by the transgene, and the genetic events involved in the genesis of neuroblastoma can be tumorigenic in more than one chronological sequence. Expand
Senescence of human fibroblasts induced by oncogenic Raf.
It is concluded that the kinase cascade initiated by Raf can regulate the expression of p16(Ink4a) and the proliferative arrest and senescence that follows and may provide a defense against neoplastic transformation when the MAP kinase signaling cascade is inappropriately active. Expand
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
Genetic evidence is obtained that FGF8 has a dual function in BA1: it promotes mesenchymal cell survival and induces a developmental program required for BA1 morphogenesis, and the data suggest that the BA1 primordium is specified into a large proximal region that is controlled by F GF8, and a small distal region that depends on other signaling molecules for its outgrowth and patterning. Expand
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
It is shown here that a DNA domain detectable by partial homology to the myc oncogene is amplified up to 140-fold in cell lines derived from different human neuroblastomas and in a neuroblastoma tumour, but not in other tumour cells showing cytological evidence for gene amplification. Expand
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
The hedgehog gene of Drosophila melanogaster encodes a secreted protein (HH) that plays a vital role in cell fate and patterning. Here we describe a protein complex that mediates signal transductionExpand
Molecular themes in oncogenesis
  • J. Bishop
  • Medicine, Biology
  • Cell
  • 25 January 1991
It seems likely that most malignancies arise from the collaborative effects of dominant and recessive lesions, andumeration of the number of tumor suppressor genes afflicted in any given tumor may be greater. Expand
A nucleoprotein complex mediates the integration of retroviral DNA.
Analysis of the native state of viral DNA in cells acutely infected by murine leukemia virus shows that the viral capsid protein is part of the active nucleoprotein complex, but recognition of the complex by only a subset of anti-capsid sera implies that the protein is constrained conformationally. Expand
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
It is demonstrated here that the DNA of normal chicken cells contains nucleotide sequences closely related to at least a portion of the transforming gene(s) of ASV; in addition, similar sequences are widely distributed among DNA of avian species and that they have diverged roughly according to phylogenetic distances among the species. Expand
Definition of regions in human c-myc that are involved in transformation and nuclear localization.
Comparison with regions that were important for transformation of Rat-1a cells revealed that some are essential for both activities, but others are important for only one or the other, suggesting that the two assays require different properties of the c-myc protein. Expand