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NOTCH1 wt Allele

Known as: Notch Homolog 1, Translocation-Associated Gene, Notch 1 wt Allele, hN1 
Human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes neurogenic locus… 
National Institutes of Health

Related topics

Related topics

16 relations
9q34.3ApoptosisCell Differentiation processCell Fate Control

Broader (1)

NOTCH1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA‐146a protects against LPS‐induced organ damage by inhibiting Notch1 in macrophage
2016
2016
miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression.
2016
2016
MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells
MiRNAs may promote or inhibit tumor recurrence and drug resistance. MiR-139-5p is reportedly downregulated in colorectal cancer… 
Highly Cited
2012
Highly Cited
2012
Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries. Chromosomal abnormalities… 
2011
2011
Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma
The tumor suppressor p53 is a key prognostic factor in hepatocellular carcinoma (HCC), yet only 35% of grade III tumors exhibit… 
2010
2010
NOTCH mutations as prognostic markers in T-ALL
Risk stratification plays a fundamental role in the treatment of acute lymphoblastic leukemia (ALL). Thus, patients harboring… 
Highly Cited
2009
Highly Cited
2009
Notch1 Signaling Sensitizes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Hepatocellular Carcinoma Cells by Inhibiting Akt/Hdm2-mediated p53 Degradation and Up…
Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis. Our previous study showed… 
Highly Cited
2009
Highly Cited
2009
Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma.
The Notch/Jagged signaling pathway is important for cellular differentiation and proliferation. Notch1/Jagged1 can either… 
Highly Cited
2006
Highly Cited
2006
Itch genetically interacts with Notch1 in a mouse autoimmune disease model.
Homozygous itchy mice develop a fatal, late-onset autoimmune-like disease due to a loss of function mutation in an ubiquitin… 
Highly Cited
2002
Highly Cited
2002
Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice
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