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Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.
TLDR
These findings provide novel mechanistic insights into epigenetic modulations induced by ROS in the process of carcinogenesis and are potentially relevant to understanding the activity of ROS in silencing various tumor suppressor genes and in subsequent tumor progression and metastasis. Expand
p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
TLDR
It is shown that Snai1 physically interacts with MDM2 by anti tag coimmunoprecipitation by acting as a “spatially aggregating force” to knock down the number of tags in the system. Expand
Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis.
TLDR
A general stepwise increase in methylating events is seen during HBV-related multistep hepatocarcinogenesis, and epigenetic changes may occur predominantly in the earlier stages of HCC development. Expand
Study of 5'-flanking region of human Cu/Zn superoxide dismutase.
TLDR
The 5'-flanking region of human Cu/Zn superoxide dismutase (SOD1) was cloned from human genomic library for the study of regulation of human SOD1 gene and several deletion analyses of promoter activity indicated that there were positive and negative regulatory regions. Expand
The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer
TLDR
A substantial role is demonstrated for the rs2853669 in HCC with TERT promoter mutation, which suggests that the combination of the rs 2853669 and the mutation indicate poor prognoses in liver cancer. Expand
Proteome analysis of hepatocellular carcinoma.
TLDR
Proteome alterations of three tissue types isolated from livers of HCC patients: normal, cirrhotic, and tumorous tissue are observed using two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Expand
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
TLDR
The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBV -related hepatocarcinogenesis, strongly suggesting vascular invasion and intrahepatic metastasis. Expand
Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter
TLDR
It is suggested that ROS may downregulate catalase through the methylation of promoter during the development of HCC. Expand
Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.
TLDR
It is shown that HBx up-regulates cyclin D1 and that this process is mediated by the NF-kappaB2(p52)/BCL-3 complex in the nucleus, which might play an important role in the HBx-mediated HCC development and progression. Expand
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing
TLDR
This study reveals the mechanism of action of PRE, which has been widely used to enhance gene expression, and identifies the TENT4–ZCCHC14 complex as a potential target for antiviral therapeutics. Expand
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