FAQ

NKX2-5 gene

Known as: NKX2.5, MOUSE, HOMOLOG OF, CARDIAC-SPECIFIC HOMEOBOX 1, CSX 
This gene plays a role in both transcriptional regulation and heart development.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
0204019952017

Related topics

Related topics

7 relations
Cell Differentiation processHomo sapiensPattern FormationPositive Regulation of Angiogenesis
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NKX2-5 wt Allele

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
NKX2-5 gene
Cell Differentiation process
dna binding
Homo sapiens
Transcriptional Regulation
Pattern Formation

Papers overview

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Highly Cited
2011
Highly Cited
2011
NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes
NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-5 locus of human embryonic stem cells… (More)
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2009
2009
Investigation of somatic NKX2-5 mutations in congenital heart disease
BACKGROUND Reports of somatic mutations found in hearts with cardiac septal defects have suggested that these mutations are… (More)
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2004
2004
Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease.
NKX2-5 is a pivotal transcription factor in heart development. Previous studies on lymphocytic DNA provided evidence of familial… (More)
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2004
2004
Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations.
NKX2-5 is a homeodomain-containing transcription factor important in cardiac development. Familial mutations in the NKX2-5 gene… (More)
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Highly Cited
2003
Highly Cited
2003
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome.
OBJECTIVES We sought to examine the importance of mutations in the cardiac transcription factor gene NKX2-5 in patients with an… (More)
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Highly Cited
2003
Highly Cited
2003
NKX2.5 mutations in patients with congenital heart disease.
OBJECTIVES The purpose of this study was to estimate the frequency of NKX2.5 mutations in specific cardiovascular anomalies and… (More)
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Highly Cited
2003
Highly Cited
2003
The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).
A cryptic chromosome rearrangement, t(5;14)(q35.1;q32.2), recently identified in pediatric acute lymphoblastic leukemia (ALL… (More)
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Highly Cited
2001
Highly Cited
2001
NKX2.5 mutations in patients with tetralogy of fallot.
BACKGROUND Recent reports have implicated mutations in the transcription factor NKX2.5 as a cause of tetralogy of Fallot (TOF… (More)
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Highly Cited
2000
Highly Cited
2000
Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.
Heterozygous mutations in the cardiac homeobox gene, NKX2-5, underlie familial cases of atrial septal defect (ASD) with severe… (More)
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Highly Cited
1998
Highly Cited
1998
Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Mutations in the gene encoding the homeobox transcription factor NKX2-5 were found to cause nonsyndromic, human congenital heart… (More)
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