Skip to search formSkip to main contentSkip to account menu

NKX2-5 gene

Known as: NKX2.5, MOUSE, HOMOLOG OF, CARDIAC-SPECIFIC HOMEOBOX 1, CSX 
This gene plays a role in both transcriptional regulation and heart development.
National Institutes of Health

Related topics

Related topics

9 relations
Cell Differentiation processHomeobox Protein Nkx-2.5, humanHomo sapiensNKX2-6 gene

Narrower (1)

NKX2-5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.
Maternal diabetes in mice induces heart defects similar to those observed in human diabetic pregnancies. Diabetes enhances… 
2014
2014
Altered transmural contractility in postmenopausal women affected by cardiac syndrome X.
2013
2013
Transcriptome-Guided Functional Analyses Reveal Novel Biological Properties and Regulatory Hierarchy of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes Crucial for Maturation
Abstract Human (h) embryonic stem cells (ESC) represent an unlimited source of cardiomyocytes (CMs); however, these… 
2013
2013
Transcriptional Defect of an Inherited NKX2-5 Haplotype Comprising a SNP, a Nonsynonymous and a Synonymous Mutation, Associated with Human Congenital Heart Disease
Germline mutations in cardiac-specific transcription factor genes have been associated with congenital heart disease (CHD) and… 
2009
2009
GATA4 and NKX2.5 gene analysis in Chinese Uygur patients with congenital heart disease.
BACKGROUND Congenital heart disease (CHD) is the most common developmental anomaly in newborns. The germline mutations in GATA4… 
Review
2005
Review
2005
Migfilin and its binding partners: from cell biology to human diseases
Links between the plasma membrane and the actin cytoskeleton are essential for maintaining tissue integrity and for controlling… 
2005
2005
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect
Highly Cited
2004
Highly Cited
2004
A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
The cardiac homeobox transcription factor CSX/NKX2-5 plays an important role in vertebrate heart development. Using a yeast two… 
Highly Cited
1995
Highly Cited
1995
A protective role for testosterone in adjuvant-induced arthritis.
We have investigated the role of the gonadal steroids testosterone (T) and progesterone in modulating: (1) the onset and severity… 
1995
1995
Assignment of cardiac homeobox gene CSX to human chromosome 5q34.
Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)