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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
TLDR
Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels. Expand
A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.
TLDR
The p130 (designated Cas for Crk‐associated substrate) is a common cellular target of phosphorylation signal via v‐Crk and v‐Src oncoproteins, and its unique structure indicates the possible role of p130Cas in assembling signals from multiple SH2‐containing molecules. Expand
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
TLDR
Results indicate that two different types of cardiac transcription factors synergistically induce cardiac development. Expand
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
TLDR
It is suggested that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis. Expand
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
TLDR
Evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes is presented, and the observation that adiponECTin improves insulin sensitivity in animal models is concluded. Expand
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
TLDR
It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens. Expand
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
TLDR
The increased number of small adipocytes and the decreased number of large adipocytes in white adipose tissues of troglitazone-treated obese rats appear to be an important mechanism by which increased expression levels of TNF-alpha and higher levels of plasma lipids are normalized, leading to alleviation of insulin resistance. Expand
A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain*
TLDR
Results indicate that VEGF-E is a novel type of endothelial growth factor, utilizing only one of the V EGF receptors, and carrying a potent mitogenic activity without affinity to heparin. Expand
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.
TLDR
Evidence is provided that p85alpha is functionally linked to the Btk pathway in antigen receptor-mediated signal transduction and is pivotal in B cell development and functions. Expand
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
TLDR
It is shown that growth hormone stimulates tyrosine phosphorylation of the receptor for epidermal growth factor (EGFR) and its association with Grb2 and at the same time stimulates MAP kinase activity in liver, an important target tissue of growth hormone. Expand
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