NKX2-5 wt Allele

Known as: Tinman Paralog (Drosophila) Gene, HLHS2, CSX 
Human NKX2-5 wild-type allele is located in the vicinity of 5q34 and is approximately 3 kb in length. This allele, which encodes homeobox protein Nkx… (More)
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND Congenital heart disease is the most common birth defect in newborns in southern China. The germline mutations in… (More)
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2009
Highly Cited
2009
Myocardial infarction is a major public health problem that causes significant mortality despite recent advances in its… (More)
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2006
2006
In the fission yeast Schizosaccharomyces pombe, oxidative stress triggers the activation of the Spc1/Sty1 mitogen-activated… (More)
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2005
Highly Cited
2005
A trial septal defect (ASD) is a common cardiovascular malformation, affecting over 1 in 1000 live births, accounting for 10% of… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES The purpose of this study was to estimate the frequency of NKX2.5 mutations in specific cardiovascular anomalies and… (More)
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2003
Highly Cited
2003
Cell transplantation could be a potential therapy for heart damage. Skeletal myoblasts have been expected to be a good cell… (More)
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2002
2002
The homeobox transcription factor CSX/NKX2.5, which is a vertebrate homologue of the Drosophila gene tinman, is essential for… (More)
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2002
2002
Recently, heterozygous mutations of human NKX2.5 were identified in patients with congenital heart disease. 2 The most common… (More)
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Highly Cited
2001
Highly Cited
2001
A DNA nonbinding mutant of the NK2 class homeoprotein Nkx2.5 dominantly inhibits cardiogenesis in Xenopus embryos, causing a… (More)
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Highly Cited
1998
Highly Cited
1998
Tinman is a Drosophila homeodomain protein that is required for formation of both visceral and cardiac mesoderm, including… (More)
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