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National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001.
BACKGROUND In the United States, birth defects affect approximately 3% of all births, are a leading cause of infant mortality, and contribute substantially to childhood morbidity. METHODSExpand
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The National Birth Defects Prevention Study
The National Birth Defects Prevention Study was designed to identify infants with major birth defects and evaluate genetic and environmental factors associated with the occurrence of birth defects.Expand
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Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.
Down syndrome is a complex genetic and metabolic disorder attributed to the presence of three copies of chromosome 21. The extra chromosome derives from the mother in 93% of cases and is due toExpand
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Diabetes mellitus and birth defects.
OBJECTIVE The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects. STUDY DESIGN This was a multicenter case-control study of mothers of infants who wereExpand
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Prepregnancy obesity as a risk factor for structural birth defects.
OBJECTIVE To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects. DESIGN An ongoing multisite, case-control study.Expand
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Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States
A decade ago, in 1992, the US Public Health Service recommended 400 μg of folic acid daily for all women of childbearing age. Four years later the Food and Drug Administration approved addingExpand
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Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project
Purpose: The population-based National Down Syndrome Project combined epidemiological and molecular methods to study congenital heart defects in Down syndrome.Methods: Between 2000 and 2004, sixExpand
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Assisted reproductive technology and major structural birth defects in the United States.
BACKGROUND With >1% of US births occurring following use of assisted reproductive technology (ART), it is critical to examine whether ART is associated with birth defects. METHODS We analyzed dataExpand
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Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study.
OBJECTIVE To estimate the association between antibacterial medications and selected birth defects. DESIGN, SETTING, AND PARTICIPANTS Population-based, multisite, case-control study of women whoExpand
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Maternal Smoking and Congenital Heart Defects
OBJECTIVES. In a population-based case-control study, we investigated the association between congenital heart defects and maternal smoking. METHODS. The National Birth Defects Prevention StudyExpand
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