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G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone marrow stem cells to the injured heart after myocardial infarction, butExpand
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p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Cardiac hypertrophy occurs as an adaptive response to increased workload to maintain cardiac function. However, prolonged cardiac hypertrophy causes heart failure, and its mechanisms are largelyExpand
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through anExpand
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Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo
Side population (SP) cells, which can be identified by their ability to exclude Hoechst 33342 dye, are one of the candidates for somatic stem cells. Although bone marrow SP cells are known to beExpand
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Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization
Pretreatment with a combination of granulocyte colony‐stimulating factor (G‐CSF) and stem cell factor (SCF) has been reported to attenuate left ventricular (LV) remodeling after acute myocardialExpand
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Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis
Although Wingless (Wg)/Wnt signaling has been implicated in heart development of multiple organisms, conflicting results have been reported regarding the role of Wnt/β-catenin pathway in cardiacExpand
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Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.
Although somatic stem cells have been reported to exist in various adult organs, there have been few reports concerning stem cells in the heart. We here demonstrate that Sca-1-positive (Sca-1+) cellsExpand
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Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation
We previously demonstrated that bone morphogenetic proteins (BMPs) induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1. Transcription factors SmadsExpand
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Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases.
During the past decade, an emerging body of evidence has accumulated that cardiac transcription factors control a cardiac gene program and play a critical role in transcriptional regulation duringExpand
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Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4*
Although the cardiac homeobox geneCsx/Nkx-2.5 is essential for normal heart development, little is known about its regulatory mechanisms. In a search for the downstream target genes of Csx/Nkx-2.5,Expand
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