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NFKBIA gene

Known as: IKBA, NUCLEAR FACTOR OF KAPPA LIGHT CHAIN GENE ENHANCER IN B CELLS INHIBITOR, NFKBIA 
This gene plays a role in signal transduction and transcriptional activation of target genes. It is also involved in the inhibition of apoptosis.
National Institutes of Health

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Related topics

10 relations
ApoptosisI-kappa B ProteinsNF-kappaB inhibitor alphaNFKBIA protein, human

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NFKBIA wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR
Human lung adenocarcinomas with activating mutations in EGFR (epidermal growth factor receptor) often respond to treatment with… 
Highly Cited
2008
Highly Cited
2008
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.
TNF-induced NF-kappaB activity shows complex temporal regulation whose different phases lead to distinct gene expression programs… 
Highly Cited
2007
Highly Cited
2007
γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of…
Unlike the tocopherols, the tocotrienols, also members of the vitamin E family, have an unsaturated isoprenoid side chain. In… 
Review
2006
Review
2006
NF-kappaB activation by reactive oxygen species: fifteen years later.
The transcription factor NF-kappaB plays a major role in coordinating innate and adaptative immunity, cellular proliferation… 
Review
2006
Review
2006
Mutations in the NF-kappaB signaling pathway: implications for human disease.
The nuclear factor-kappa B (NF-kappaB) signaling pathway is a multi-component pathway that regulates the expression of hundreds… 
Highly Cited
2004
Highly Cited
2004
Regulation of Cu/Zn-Superoxide Dismutase Expression via the Phosphatidylinositol 3 Kinase/Akt Pathway and Nuclear Factor-κB
Aerobic cells adjust the expression of antioxidant enzymes to maintain reactive oxygen species within tolerable levels. In… 
Highly Cited
2002
Highly Cited
2002
Mechanisms of constitutive NF‐κB activation in human prostate cancer cells
Activation of the NF‐κB transcription factor has been previously demonstrated in two androgen receptor negative prostate cancer… 
Highly Cited
2000
Highly Cited
2000
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
Agents that can suppress the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) may be able to block… 
Highly Cited
2000
Highly Cited
2000
Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor…
Limited studies have indicated that some chemotherapy agents activate the transcription factor nuclear factor-kappaB (NF-kappaB… 
Review
1998
Review
1998
IκB–NF-κB Structures At the Interface of Inflammation Control
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