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NFKBIA gene

Known as: IKBA, NUCLEAR FACTOR OF KAPPA LIGHT CHAIN GENE ENHANCER IN B CELLS INHIBITOR, NFKBIA 
This gene plays a role in signal transduction and transcriptional activation of target genes. It is also involved in the inhibition of apoptosis.
National Institutes of Health

Related topics

Related topics

10 relations
ApoptosisI-kappa B ProteinsNF-kappaB inhibitor alphaNFKBIA protein, human

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NFKBIA wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
2006
2006
Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB.
Nuclear factor kappaB (NF-kappaB) transcription factors regulate genes responsible for critical cellular processes. IkappaBalpha… 
Highly Cited
2005
Highly Cited
2005
Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.
Nuclear factor-kappaB (NF-kappaB) activation has been shown to be both antiapoptotic and proapoptotic depending on the stimulus… 
Highly Cited
2004
Highly Cited
2004
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-KB through suppression of IKBA phosphorylation
Epidemiologic studies suggest that diet rich in plantderived foods plays an important role in the prevention of prostate cancer… 
Highly Cited
2004
Highly Cited
2004
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.
Epidemiologic studies suggest that diet rich in plant-derived foods plays an important role in the prevention of prostate cancer… 
Review
2003
Review
2003
Deregulation of NF-κB and its upstream kinases in cancer
The transcription factor NF-κB is known for its function in regulating immune and inflammatory responses. However, recent… 
Highly Cited
2002
Highly Cited
2002
Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells.
Antigen (Ag)-stimulated mast cells induce synthesis and production of cytokines including tumor necrosis factor (TNF)-alpha and… 
Highly Cited
2000
Highly Cited
2000
NF-κB Is Required for the Positive Selection of CD8+ Thymocytes1
To examine the role of NF-κB in T cell development, we analyzed thymocyte ontogeny in transgenic (mutant I-κBα (mI-κBα)) mice… 
Highly Cited
2000
Highly Cited
2000
Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes.
1992
1992
Related subunits of NF-kappa B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.
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