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NFAT5 wt Allele

Known as: TONEBP, NF-AT5, KIAA0827 
Human NFAT5 wild-type allele is located in the vicinity of 16q22.1 and is approximately 140 kb in length. This allele, which encodes nuclear factor… 
National Institutes of Health

Related topics

Related topics

11 relations
16q22.1Axon GuidanceB Cell Receptor Signaling PathwayCellular Stress Response

Broader (1)

NFAT5 gene

Narrower (1)

NFAT5 protein, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways.
TonEBP (tonicity-responsive enhancer binding protein) is a transcription factor that promotes cellular accumulation of organic… 
Highly Cited
2006
Highly Cited
2006
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.
High NaCl causes DNA double-strand breaks and activates the transcription factor, TonEBP/OREBP, resulting in increased… 
Highly Cited
2006
Highly Cited
2006
TonEBP/OREBP Is a Regulator of Nucleus Pulposus Cell Function and Survival in the Intervertebral Disc*
The nucleus pulposus is an aggrecan-rich hydrated tissue that permits the intervertebral disc to resist compressive loads… 
Highly Cited
2005
Highly Cited
2005
High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA.
Hypertonicity increases mRNA and protein abundance of the transcription factor tonicity-responsive enhancer/osmotic response… 
Highly Cited
2004
Highly Cited
2004
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
High NaCl activates the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein (TonEBP/OREBP… 
Highly Cited
2004
Highly Cited
2004
Osmotic Response Element-binding Protein (OREBP) Is an Essential Regulator of the Urine Concentrating Mechanism*
OREBP (osmotic response element-binding protein), also called TonEBP or NFAT5, is thought to induce the expression of genes that… 
Highly Cited
2002
Highly Cited
2002
Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration
Hypertonicity-induced binding of the transcription factor TonEBP/OREBP to its cognate DNA element, ORE/TonE, is associated with… 
Review
2002
Review
2002
TonEBP transcriptional activator in the cellular response to increased osmolality
Abstract. TonEBP is a member of the Rel family of transcriptional activators, distinct from other members NFκB and NFAT. In the… 
Highly Cited
2002
Highly Cited
2002
Fyn and p38 Signaling Are Both Required for Maximal Hypertonic Activation of the Osmotic Response Element-binding Protein/Tonicity-responsive Enhancer-binding Protein (OREBP/TonEBP)*
When cells are challenged by hyperosmotic stress, one of the crucial adaptive responses is the expression of osmoprotective genes… 
Highly Cited
2000
Highly Cited
2000
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1
NFAT DNA binding complexes regulate programs of cellular activation and differentiation by translating receptor-dependent… 
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