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16q22.1

A chromosome band present on 16q
National Institutes of Health

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19 relations
16qACD wt AlleleCDH1 wt AlleleCDH3 wt Allele
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Highly Cited
2009
Highly Cited
2009
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.
Closely located at the tumor suppressor locus 16q22.1, CKLF-like MARVEL transmembrane domain-containing member 3 and 4 (CMTM3 and… 
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Highly Cited
2008
Highly Cited
2008
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of… 
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Review
2001
Review
2001
The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
E-cadherin is a cell–cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems… 
Highly Cited
1997
Highly Cited
1997
The E‐cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas
Our study was designed to clarify the significance of silencing the E‐cadherin gene, which is located on 16q22.1, due to CpG… 
Highly Cited
1996
Highly Cited
1996
Autosomal dominant spinocerebellar ataxia with sensory axonal neuropathy (SCA4): clinical description and genetic localization to chromosome 16q22.1.
The hereditary ataxias represent a clinically and genetically heterogeneous group of neurodegenerative disorders. Various… 
Highly Cited
1996
Highly Cited
1996
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.
We have analysed a series of 49 human breast cancers for mutations in the entire coding region plus flanking intron sequences of… 
Highly Cited
1996
Highly Cited
1996
Molecular Cloning and Functional Expression of the K-Cl Cotransporter from Rabbit, Rat, and Human
We report the cloning, sequence analysis, tissue distribution, and functional expression of the K-Cl cotransport protein, KCC1… 
Highly Cited
1995
Highly Cited
1995
E‐cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
Compelling experimental evidence exists for a potent invasion suppressor role of the cell‐cell adhesion molecule E‐cadherin. In… 
Highly Cited
1995
Highly Cited
1995
Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1.
A human genomic clone for a novel fifth member of the Na+/H+ exchanger (NHE) family, NHE5 (gene symbol SLC9A5), has been isolated… 
Highly Cited
1990
Highly Cited
1990
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.
Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the… 
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