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NFAT5 protein, human

Known as: TonEBP, T-Cell Transcription Factor NFAT5, Nuclear Factor of Activated T-Cells 5 
Nuclear factor of activated T-cells 5 (1531 aa, ~166 kDa) is encoded by the human NFAT5 gene. This protein is involved in the modulation of… 
National Institutes of Health

Related topics

Related topics

14 relations
Axon GuidanceB Cell Receptor Signaling PathwayCellular Stress ResponseDNA-Binding Proteins

Broader (2)

NFAT5 wt AlleleTRANSCRIPTION FACTOR

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
Nucleus pulposus (NP) cells reside in a physiologically hyperosmotic environment within the intervertebral disc. TonEBP/NFAT5 is… 
2016
2016
Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress
Purpose: Macular edema, a frequently encountered complication of diabetic retinopathy (DR), results from alterations of the blood… 
2012
2012
Sepsis-induced urinary concentration defect is related to nitric oxide–dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2*
Objective:Acute kidney injury associated with reduced urinary concentration is a frequent and severe complication during sepsis… 
2008
2008
Novel Nuclear Localization Signal Regulated by Ambient Tonicity in Vertebrates*
TonEBP is a Rel domain-containing transcription factor implicated in adaptive immunity, viral replication, and cancer. In the… 
2007
2007
Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions
The cells of the renal medulla produce large amounts of prostaglandin E2 (PGE2) via cyclooxygenases (COX)‐1 and ‐2. PGE2 is well… 
2007
2007
Hypertonic-induced lamin A/C synthesis and distribution to nucleoplasmic speckles is mediated by TonEBP/NFAT5 transcriptional activator.
Highly Cited
2005
Highly Cited
2005
High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA.
Hypertonicity increases mRNA and protein abundance of the transcription factor tonicity-responsive enhancer/osmotic response… 
2005
2005
Transgenic Mice Expressing Dominant-negative Osmotic-response Element-binding Protein (OREBP) in Lens Exhibit Fiber Cell Elongation Defect Associated with Increased DNA Breaks*
Osmotic-response element-binding protein (OREBP), also known as TonEBP or NFAT5, is thought to be responsible for the induction… 
Highly Cited
2003
Highly Cited
2003
Silencing of TonEBP/NFAT5 transcriptional activator by RNA interference.
TonEBP is a transcriptional activator that is expressed throughout development in many tissues and cell types. In the kidney… 
2002
2002
Dimerization is required for phosphorylation and DNA binding of TonEBP/NFAT5.
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