Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
- H. Miyakawa, S. K. Woo, S. C. Dahl, J. Handler, H. Kwon
- BiologyProceedings of the National Academy of Sciences…
- 2 March 1999
CDNA cloning of human TonE binding protein (TonEBP) is reported, a transcription factor that stimulates transcription through its binding to TonE sequences via a Rel-like DNA binding domain that plays a key role in hypertonicity-induced transcriptional stimulation of SMIT, sodium/chloride/betaine cotransporter, and aldose reductase.
Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.
- H. Kwon, A. Yamauchi, J. Handler
- BiologyJournal of Biological Chemistry
- 25 March 1992
Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity.
- A. Yamauchi, S. Uchida, J. Handler
- BiologyJournal of Biological Chemistry
- 5 January 1992
Bidirectional regulation of tonicity-responsive enhancer binding protein in response to changes in tonicity.
- S. K. Woo, S. C. Dahl, J. Handler, H. Kwon
- BiologyAJP - Renal Physiology
- 1 June 2000
Exposure to hypotonic medium leads to a dramatic downregulation of TonEBP both in abundance and nuclear distribution, indicating that under isotonic conditions, TonE BP is at a low-level activated state and can respond to both increase and decrease in tonicity.
The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress.
- M. Takenaka, A. Preston, H. Kwon, J. Handler
- BiologyJournal of Biological Chemistry
- 25 November 1994
TonEBP/NFAT5 Stimulates Transcription of HSP70 in Response to Hypertonicity
It is concluded that TonEBP is a master regulator of the renal medulla for cellular protection against high osmolality via organic osmolytes and molecular chaperones.
Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity.
- S. Uchida, H. Kwon, A. Yamauchi, A. Preston, F. Marumo, J. Handler
- BiologyProceedings of the National Academy of Sciences…
- 1 August 1993
Northern hybridization indicates that mRNA for the taurine transporter is present in renal cortex and medulla, ileal mucosa, brain, liver, and heart, suggesting that regulation of transport activity by medium hypertonicity occurs at the level of mRNA accumulation.
Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region*
- J. Rim, M. Atta, S. C. Dahl, G. Berry, J. Handler, H. Kwon
- Biology, ChemistryJournal of Biological Chemistry
- 7 August 1998
In vivo methylation experiments demonstrated that exposure of cells to hypertonicity increases the binding of tonicity-responsive enhancer binding protein to the enhancer sites, indicating that all of these enhancers are involved in the transcriptional stimulation.
Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity.
- S. Uchida, H. Kwon, A. Yamauchi, A. Preston, F. Marumo, J. Handler
- BiologyProceedings of the National Academy of Sciences…
- 1 September 1992
Abstract
Cells in the hypertonic renal medulla maintain their intracellular ion concentration at isotonic levels, despite much higher concentrations of extracellular electrolytes, by accumulating…
Cell volume regulated transporters of compatible osmolytes.
- H. Kwon, J. Handler
- BiologyCurrent Opinion in Cell Biology
- 1995
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