NEDD4 gene

Known as: NEDD4-1, Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase Gene, RPF1 
This gene may play a role in viral infection and tumor suppression.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Regulation of renal Na(+) transport is essential for controlling blood pressure, as well as Na(+) and K(+) homeostasis… (More)
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Highly Cited
2010
Highly Cited
2010
Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections… (More)
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Highly Cited
2008
Highly Cited
2008
Interferons regulate diverse immune functions through the transcriptional activation of hundreds of genes involved in anti-viral… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Serum- and glucocorticoid-inducible kinase 1 (SGK1) inhibits the ubiquitin ligase neuronal cell expressed… (More)
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Highly Cited
2004
Highly Cited
2004
Na(v)1.5, the cardiac isoform of the voltage-gated Na+ channel, is critical to heart excitability and conduction. However, the… (More)
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Highly Cited
2003
Highly Cited
2003
The adapter protein Grb10 belongs to a superfamily of related proteins, including Grb7, -10, and -14 and Caenorhabditis elegans… (More)
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Highly Cited
2001
Highly Cited
2001
Nedd4 is a ubiquitin protein ligase composed of a C2 domain, three (or four) WW domains and a ubiquitin ligase Hect domain. Nedd4… (More)
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Highly Cited
2001
Highly Cited
2001
Liddle's syndrome is a form of inherited hypertension linked to mutations in the genes encoding the epithelial Na+ channel (ENaC… (More)
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Highly Cited
1999
Highly Cited
1999
Liddle's syndrome is an inherited form of hypertension linked to mutations in the epithelial Na+ channel (ENaC). ENaC is composed… (More)
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