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NEDD4 gene

Known as: NEDD4-1, Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase Gene, RPF1 
This gene may play a role in viral infection and tumor suppression.
National Institutes of Health

Related topics

Related topics

3 relations
E3 Ubiquitin-Protein Ligase NEDD4, HumanUbiquitination

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NEDD4 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.
Highly Cited
2010
Highly Cited
2010
Lysine 63-linked Polyubiquitination of the Dopamine Transporter Requires WW3 and WW4 Domains of Nedd4-2 and UBE2D Ubiquitin-conjugating Enzymes*
RNA interference screen previously revealed that a HECT-domain E3 ubiquitin ligase, neuronal precursor cell expressed… 
2010
2010
Down-regulation of Intestinal Apical Calcium Entry Channel TRPV6 by Ubiquitin E3 Ligase Nedd4-2*
Nedd4-2 is an archetypal HECT ubiquitin E3 ligase that disposes target proteins for degradation. Because of the proven roles of… 
Highly Cited
2008
Highly Cited
2008
Avian Sarcoma Virus and Human Immunodeficiency Virus, Type 1 Use Different Subsets of ESCRT Proteins to Facilitate the Budding Process*
Members of the Nedd4 family of E3 ubiquitin ligases bind the L domain in avian sarcoma virus (ASV) Gag and facilitate viral… 
Highly Cited
2007
Highly Cited
2007
NEDD4‐2 as a potential candidate susceptibility gene for epileptic photosensitivity
Photosensitive seizures occur most commonly in childhood and adolescence, usually as a manifestation of complex idiopathic… 
Highly Cited
2005
Highly Cited
2005
Nedd4-2 isoforms differentially associate with ENaC and regulate its activity.
Mutations that disrupt a PY motif in epithelial Na(+) channel (ENaC) subunits increase surface expression of Na(+) channels in… 
Highly Cited
2003
Highly Cited
2003
Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling
ABSTRACT Nedd4 family ubiquitin protein ligases (E3s) specifically associate with latent membrane protein 2A (LMP2A) of Epstein… 
2003
2003
The Grb 10 / Nedd 4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor
The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor Andrea… 
Highly Cited
1999
Highly Cited
1999
mGrb10 Interacts with Nedd4*
We have utilized the yeast two-hybrid system to identify proteins interacting with mouse Grb10, an adapter protein known to… 
Highly Cited
1998
Highly Cited
1998
Human ubiquitin‐protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin‐conjugating enzymes
Nedd4 is a ubiquitin‐protein ligase containing a calcium/lipid‐binding domain, multiple WW domains and a C‐terminal Hect domain… 
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