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E3 Ubiquitin-Protein Ligase NEDD4, Human

Known as: E3 Ubiquitin-Protein Ligase NEDD4, Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4, Receptor-Potentiating Factor 1 
E3 ubiquitin-protein ligase NEDD4 (1000 aa, ~115 kDa) is encoded by the human NEDD4 gene. This protein is involved in the transfer of ubiquitin to… Expand
National Institutes of Health

Related topics

Related topics

8 relations
E3 Ubiquitin-Protein Ligase Makorin-1, humanEnzyme GeneHACE1 protein, humanHomo sapiens
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
&NA; Pancreatic cancer (PC) is one of the most fatal cancers worldwide. The incidence and death rates are still increasing for PC… Expand
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2017
2017
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells
ABSTRACT The neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) plays a pivotal oncogenic role in… Expand
2016
2016
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells
Peroxisome proliferator–activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose… Expand
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Highly Cited
2016
Highly Cited
2016
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function
Significance The voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the… Expand
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Highly Cited
2015
Highly Cited
2015
Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
Inhibition of placental mechanistic target of rapamycin (mTOR) signalling, which activates NEDD4-2 (neural precursor cell… Expand
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2015
2015
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy
Nedd4 (neural precursor cell expressed developmentally down‐regulated protein 4) is a member of the HECT E3 ubiquitin ligases… Expand
2014
2014
Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein*
Background: Nedd4-1 catalyzes the Lys-63-linked ubiquitination of aS. Results: The Lys-63-linked ubiquitination of aS by Nedd4-1… Expand
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2014
2014
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through… Expand
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2012
2012
Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Kif26b expression is restricted… Expand
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Highly Cited
1997
Highly Cited
1997
Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases*
In most instances, the transfer of ubiquitin to target proteins is catalyzed by the action of ubiquitin protein ligases (E3s… Expand
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