Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

E3 Ubiquitin-Protein Ligase NEDD4, Human

Known as: E3 Ubiquitin-Protein Ligase NEDD4, Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4, Receptor-Potentiating Factor 1 
E3 ubiquitin-protein ligase NEDD4 (1000 aa, ~115 kDa) is encoded by the human NEDD4 gene. This protein is involved in the transfer of ubiquitin to… Expand
National Institutes of Health

Related topics

Related topics

8 relations
E3 Ubiquitin-Protein Ligase Makorin-1, humanEnzyme GeneHACE1 protein, humanHomo sapiens
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast.
Neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) is an E3 ubiquitin ligase that regulates animal… Expand
Is this relevant?
2017
2017
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells
ABSTRACT The neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) plays a pivotal oncogenic role in… Expand
Is this relevant?
2016
2016
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells
Peroxisome proliferator–activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2016
2016
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function
Significance The voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
Inhibition of placental mechanistic target of rapamycin (mTOR) signalling, which activates NEDD4-2 (neural precursor cell… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2015
2015
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
OBJECTIVES Nedd4 (neural precursor cell expressed developmentally down-regulated protein 4) is a member of the HECT E3 ubiquitin… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
The cardiac electrical disorder long QT syndrome (LQTS) pre-disposes affected individuals to ventricular arrhythmias and sudden… Expand
Is this relevant?
2014
2014
Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein*
Background: Nedd4-1 catalyzes the Lys-63-linked ubiquitination of aS. Results: The Lys-63-linked ubiquitination of aS by Nedd4-1… Expand
  • figure 3
  • figure 4
  • figure 5
  • figure 7
  • figure 8
Is this relevant?
2014
2014
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1997
1997
Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases*
In most instances, the transfer of ubiquitin to target proteins is catalyzed by the action of ubiquitin protein ligases (E3s… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE