FAQ

E3 Ubiquitin-Protein Ligase NEDD4, Human

Known as: E3 Ubiquitin-Protein Ligase NEDD4, Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4, Receptor-Potentiating Factor 1 
E3 ubiquitin-protein ligase NEDD4 (1000 aa, ~115 kDa) is encoded by the human NEDD4 gene. This protein is involved in the transfer of ubiquitin to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2016
012319972016

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7 relations
E3 Ubiquitin-Protein Ligase Makorin-1, humanEnzyme GeneHACE1 protein, humanHomo sapiens
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Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
E3 Ubiquitin-Protein Ligase NEDD4, Human
Homo sapiens
Enzyme Gene
NEDD4 gene
Ligase Gene
Ubiquitin-Protein Ligase Complexes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells.
The neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) plays a pivotal oncogenic role in various… (More)
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2016
2016
Flavanoids as Potential NEDD-4 Inhibitors: In Silico Discovery Using Molecular Docking and ADME Studies
NEDD-4 are closely related E3 ubiquitin-protein ligases that include a C2 domain, three or four WW domains and a catalytic HECT… (More)
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2015
2015
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
OBJECTIVES Nedd4 (neural precursor cell expressed developmentally down-regulated protein 4) is a member of the HECT E3 ubiquitin… (More)
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2014
2014
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through… (More)
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2014
2014
Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.
α-Synuclein (aS) is a major constituent of Lewy bodies, which are not only a pathological marker for Parkinson disease but also a… (More)
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2012
2012
Analysis of the Gene Expression Profile of Curcumin-Treated Kidney on Endotoxin-Induced Renal Inflammation
Acute or chronic kidney inflammation is closely related to the progress of kidney diseases. Curcumin, a yellow pigment present in… (More)
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2012
2012
Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Kif26b expression is restricted… (More)
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Review
2000
Review
2000
Activation of the Amiloride-Sensitive Epithelial Sodium Channel by the Serine Protease mCAP1 Expressed in a Mouse Cortical Collecting Duct Cell Line GRÉGOIRE VUAGNIAUX,* VÉRONIQUE VALLET,* NICOLE…
This study examines whether serine proteases can activate the amiloride-sensitive sodium channel (ENaC) in mammalian kidney… (More)
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1997
1997
Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.
In most instances, the transfer of ubiquitin to target proteins is catalyzed by the action of ubiquitin protein ligases (E3s… (More)
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1997
1997
Identification of novel human WW domain-containing proteins by cloning of ligand targets.
A recently described protein module consisting of 35-40 semiconserved residues, termed the WW domain, has been identified in a… (More)
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