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E3 Ubiquitin-Protein Ligase NEDD4, Human
Known as:
E3 Ubiquitin-Protein Ligase NEDD4
, Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4
, Receptor-Potentiating Factor 1
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E3 ubiquitin-protein ligase NEDD4 (1000 aa, ~115 kDa) is encoded by the human NEDD4 gene. This protein is involved in the transfer of ubiquitin to…
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National Institutes of Health
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Related topics
Related topics
8 relations
E3 Ubiquitin-Protein Ligase Makorin-1, human
Enzyme Gene
HACE1 protein, human
Homo sapiens
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
Jingna Su
,
Xiu-xia Zhou
,
+6 authors
Zhiwei Wang
Biochemical pharmacology
2017
Corpus ID: 24390354
2017
2017
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells
W. Wen
,
Jingying Li
,
+6 authors
Renrui Kuang
Cell cycle
2017
Corpus ID: 13898518
ABSTRACT The neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) plays a pivotal oncogenic role in…
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2016
2016
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells
Jing Jing Li
,
Ruishan Wang
,
+4 authors
F. Liao
Scientific reports
2016
Corpus ID: 17514448
Peroxisome proliferator–activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose…
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Highly Cited
2016
Highly Cited
2016
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function
E. Dustrude
,
A. Moutal
,
Xiaofang Yang
,
Yuying Wang
,
M. Khanna
,
R. Khanna
Proceedings of the National Academy of Sciences
2016
Corpus ID: 4881855
Significance The voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the…
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Highly Cited
2015
Highly Cited
2015
Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
Yi-Yung Chen
,
F. Rosario
,
M. A. Shehab
,
T. Powell
,
Madhulika B. Gupta
,
T. Jansson
Clinical science
2015
Corpus ID: 8000597
Inhibition of placental mechanistic target of rapamycin (mTOR) signalling, which activates NEDD4-2 (neural precursor cell…
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2015
2015
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy
Yuyin Li
,
Li Zhang
,
+4 authors
Aipo Diao
Cell proliferation
2015
Corpus ID: 205035498
Nedd4 (neural precursor cell expressed developmentally down‐regulated protein 4) is a member of the HECT E3 ubiquitin ligases…
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2014
2014
Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein*
N. Sugeno
,
T. Hasegawa
,
+12 authors
A. Takeda
The Journal of Biological Chemistry
2014
Corpus ID: 36866322
Background: Nedd4-1 catalyzes the Lys-63-linked ubiquitination of aS. Results: The Lys-63-linked ubiquitination of aS by Nedd4-1…
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2014
2014
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
Di-Feng Fang
,
Kun He
,
+14 authors
Weihua Li
Nature communications
2014
Corpus ID: 6899537
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through…
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2012
2012
Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development
T. Terabayashi
,
M. Sakaguchi
,
+5 authors
R. Nishinakamura
PloS one
2012
Corpus ID: 731228
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Kif26b expression is restricted…
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Highly Cited
1997
Highly Cited
1997
Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases*
S. Hatakeyama
,
J. P. Jensen
,
A. Weissman
The Journal of Biological Chemistry
1997
Corpus ID: 23054624
In most instances, the transfer of ubiquitin to target proteins is catalyzed by the action of ubiquitin protein ligases (E3s…
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