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NEDD4 wt Allele

Known as: NEDD4-1, RPF1, Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 Gene 
Human NEDD4 wild-type allele is located in the vicinity of 15q and is approximately 167 kb in length. This allele, which encodes E3 ubiquitin-protein… 
National Institutes of Health

Related topics

Related topics

4 relations
Chromosome 15 Short ArmHomo sapiensUbiquitination

Broader (1)

NEDD4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The NEDD4‐1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma
E3 ubiquitin ligases primarily determine the substrate specificity of the ubiquitin‐proteasome system and play an essential role… 
2018
2018
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma
Background: The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively… 
2016
2016
NEDD4-1 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis via the PI3K/Akt pathway
Activation of the Akt pathway has been shown to protect the heart from ischaemia/reperfusion (I/R) injury. NEDD4-1 has been shown… 
2016
2016
Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.
Voltage-dependent potassium channels (Kv) go beyond the stabilization of the resting potential and regulate biochemical pathways… 
2015
2015
NEDD4-1 and PTEN expression in keloid scarring.
Keloid scarring remains a major problem in plastic surgery. The aim of this study was to determine the expression of the PTEN… 
Highly Cited
2014
Highly Cited
2014
The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation
Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor… 
2014
2014
Molecular Cloning of Rat and Porcine Retina-derived POU Domain Factor 1 (POU6F2) from a Pituitary cDNA Library
Homeobox transcription factors are known to play crucial roles in the anterior lobe of the pituitary gland. During molecular… 
2013
2013
NEDD4-1 Regulates Migration and Invasion of Glioma Cells through CNrasGEF Ubiquitination In Vitro
Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) plays a great role in tumor cell growth, but its… 
Highly Cited
2012
Highly Cited
2012
Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration
The importance of ubiquitin E3 ligases in neurodegeneration is being increasingly recognized. The crucial role of NEDD4-1 in… 
2012
2012
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
The expression of phosphatase and tensin homolog (PTEN), a tumor suppressor gene, is frequently down-regulated in gastric… 
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