• Publications
  • Influence
The KCNQ1 potassium channel: from gene to physiological function.
TLDR
The current knowledge about the KCNQ1 channel is reviewed with a major focus on interacting proteins and physiological functions, capable of modulating the properties of the channel complexes. Expand
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.
TLDR
This study shows that Nedd4-dependent ubiquitination of Na(v) channels may represent a general mechanism regulating the excitability of neurons and myocytes via modulation of channel density at the plasma membrane. Expand
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.
TLDR
Sk2 and SK3 were down-regulated and had reduced functional importance in chronic AF, and pharmacological inhibition of SK channels may be a putative atrial-selective target for future antiarrhythmic drug therapy. Expand
KCNE4 is an inhibitory subunit to the KCNQ1 channel
TLDR
It is demonstrated that KCNE4 is an inhibitory subunit to KCNQ1 channels, a membrane protein belonging to a family of single transmembrane domain proteins known to have dramatic effect on the gating of certain potassium channels. Expand
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.
TLDR
The results suggest that KCNQ1 internalization and stability is physiologically regulated by its Nedd4/Nedd4-like-dependent ubiquitylation, and this mechanism may thereby be important in regulating the surface density of the KCnQ1 channels in cardiomyocytes and other cell types. Expand
KCNQ4 channel activation by BMS-204352 and retigabine
TLDR
It is shown that KCNQ4 channels, stably expressed in HEK293 cells, were activated by retigabine and BMS-204352 in a reversible and concentration-dependent manner in the concentration range 0.1-10 microM. Expand
Pharmacological modulation of SK3 channels
TLDR
The functional expression of SK3 is reported in HEK293 and a broad pharmacological profile for these channels is demonstrated and both 4-AP and bicuculline are shown to inhibit SK3 channels at concentrations lower than those used for brain slice recordings. Expand
Inhibition of Small-Conductance Ca2+-Activated K+ Channels Terminates and Protects Against Atrial Fibrillation
TLDR
Inhibition of SK channels prolongs atrial effective refractory period without affecting QT interval and prevents and terminates AF ex vivo and in vivo, thus offering a promising new therapeutic opportunity in the treatment of AF. Expand
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.
TLDR
It is speculated that since KCNE5 is expressed in cardiac tissue it may here along with the KCNE1 beta-subunit regulate KCNQ1 channels, and it is possible thatKCNE5 shapes the I(Ks) current in certain parts of the mammalian heart. Expand
Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts
TLDR
Investigation of steady-state RNA levels by quantitative polymerase chain reaction of ion channels, transporters, connexin 43, and miR-1 in 11 end-stage HF and seven nonfailing hearts reveals altered expression of several cardiac ion channels and transporter which may in part explain the increased susceptibility to arrhythmia in end-state failing hearts. Expand
...
1
2
3
4
5
...