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CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
TLDR
It is reported here that temperature-sensitive mutants defective in genes CDC42 and CDC43, like cdc24 mutants, fail to bud but continue growth at restrictive temperature, and thus arrest as large unbudded cells, supporting the hypothesis that the events associated with budding and those of the nuclear cycle represent two independent pathways within the cell cycle.
Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death
TLDR
By DNA transfection into human B cells, it is shown that protection from apoptosis is conferred through expression of a single EBV latent protein, the latent membrane protein LMP 1, and it is demonstrated that L MP 1 mediates this effect by up-regulating expression of the cellular oncogene bcl-2.
Herpesvirus Entry: an Update
TLDR
The purpose of this review is to summarize recent findings on the entry of alpha- and gammaherpesviruses and on structure-function studies of their entry receptors and viral ligands.
Fusing structure and function: a structural view of the herpesvirus entry machinery
TLDR
Structural studies have accelerated the understanding of HSV and EBV binding and fusion by revealing the conformational changes that occur on virus–receptor binding, depicting potential sites of functional protein and lipid interactions, and identifying the probable viral fusogen.
The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction.
TLDR
Analysis of Syk phosphorylation before and after BCR cross-linking in the LMP2A mutant ITAM LCLs compared with wild-type EBV L CLs indicates a specific role of the L MP2A ITAM on the Lmp2A-mediated negative effect on the Syk PTK.
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.
TLDR
Cross-linking slg on cells transformed by LMP2 null mutant EBV recombinants triggers the same protein tyrosine kinase cascade as in noninfected B lymphocytes, consistent with a model in which L MP2 is a constitutive dominant negative modulator of slg receptor signaling through its effects on Lyn, Syk, or regulators of these kinases.
Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B
TLDR
The crystal structure of the secreted EBV gB ectodomain is reported, which forms 16-nm long spike-like trimers, structurally homologous to the postfusion trimers of the fusion protein G of vesicular stomatitis virus (VSV).
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B‐cell receptor activation
TLDR
Results suggest that Btk maintains increased intracellular calcium levels by controlling a Tg‐sensitive, IP3‐gated calcium store(s) that regulates store‐operated calcium entry.
Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture
TLDR
The results lead to the conclusion that the US3 open reading frame encodes a virus-specific protein kinase that is not required for virus growth in cells in culture.
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
TLDR
It is demonstrated that four cellular proteins bind specifically to two PPPPY (PY) motifs present within the LMP2A amino-terminal domain, suggesting that LMP1A recruits Nedd4-like ubiquitin-protein ligases and B-cell signal transduction molecules, resulting in the degradation of L MP2A and Lyn by a ubiquitIn-dependent mechanism.
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