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NAD-Dependent Deacetylase Sirtuin-2
Known as:
Silent Information Regulator 2
, EC 3.5.1.-
, SIR2-Like Protein 2
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NAD-dependent deacetylase sirtuin-2 (389 aa, ~43 kDa) is encoded by the human SIRT2 gene. This protein plays a role in the deacetylation of tubulin.
National Institutes of Health
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Related topics
Related topics
7 relations
Cell division
Cytoskeleton
Deacetylation
Enzyme Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Sirtuins as emerging anti-parasitic targets.
Weiping Zheng
European journal of medicinal chemistry
2013
Corpus ID: 33728924
2012
2012
Anti-leishmanial activity of the bisnaphthalimidopropyl derivatives.
J. Tavares
,
A. Ouaissi
,
A. Silva
,
P. Lin
,
N. Roy
,
A. Cordeiro-da-Silva
Parasitology international
2012
Corpus ID: 20463272
2011
2011
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Neuroblastoma Cells: Role of Sirtuin 1
J. Pizarro
,
E. Verdaguer
,
+5 authors
A. Camins
Neurochemical Research
2011
Corpus ID: 20435374
Resveratrol prolongs lifespan and prevent cancer formation; however, the mechanisms are not understood. Here we evaluated the…
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2009
2009
Molecular cloning and characterization of porcine sirtuin genes.
D. Jin
,
H. Tan
,
+5 authors
Z. Q. Yang
Comparative Biochemistry and Physiology Part B…
2009
Corpus ID: 21488121
2008
2008
Genomewide Screen for Negative Regulators of Sirtuin Activity in Saccharomyces cerevisiae Reveals 40 Loci and Links to Metabolism
Ryan M. Raisner
,
H. Madhani
Genetics
2008
Corpus ID: 20822055
Sirtuins are conserved proteins implicated in myriad key processes including gene control, aging, cell survival, metabolism, and…
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2007
2007
Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.
Gemma Reverter-Branchat
,
E. Cabiscol
,
J. Tamarit
,
M. Sorolla
,
M. Angeles de la Torre
,
J. Ros
Microbiology
2007
Corpus ID: 41671577
Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces…
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Highly Cited
2006
Highly Cited
2006
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
U. Mahlknecht
,
A. Ho
,
S. Voelter-Mahlknecht
International Journal of Oncology
2006
Corpus ID: 32962132
Sirtuin 6 (SIRT6) is a member of the sirtuin deacetylases (sirtuins), which are derivatives of the yeast Silent information…
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2006
2006
Caspase-mediated changes in Sir2alpha during apoptosis.
Shizue Ohsawa
,
M. Miura
FEBS Letters
2006
Corpus ID: 41987423
Silent information regulator 2 (Sir2) is an NAD(+)-dependent histone deacetylase that establishes repressive chromatin status and…
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Highly Cited
2005
Highly Cited
2005
Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.
B. Vergnes
,
Laurent Vanhille
,
A. Ouaissi
,
D. Sereno
Acta Tropica
2005
Corpus ID: 20037579
1998
1998
Leishmania major: Cell type dependent distribution of a 43 kDa antigen related to silent information regulatory‐2 protein family
K. Zemzoumi
,
D. Sereno
,
C. François
,
E. Guilvard
,
J. Lemesre
,
Ali Oualssi
Biology of the Cell
1998
Corpus ID: 24471190
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