FAQ

NAD-Dependent Deacetylase Sirtuin-2

Known as: Silent Information Regulator 2, EC 3.5.1.-, SIR2-Like Protein 2 
NAD-dependent deacetylase sirtuin-2 (389 aa, ~43 kDa) is encoded by the human SIRT2 gene. This protein plays a role in the deacetylation of tubulin.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Related topics

Related topics

8 relations
Cell divisionCytoskeletonDeacetylationEnzyme Gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
NAD-Dependent Deacetylase Sirtuin-2
Hydrolysis
Cell division
Microtubules
Cytoskeleton
Deacetylation

Papers overview

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2011
2011
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
The Sirtuin family of proteins (SIRT) encode a group of evolutionarily conserved, NAD-dependent histone deacetylases, involved in… (More)
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2009
2009
Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse.
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information… (More)
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2009
2009
Calorie restriction effects on silencing and recombination at the yeast rDNA.
Aging research has developed rapidly over the past decade, identifying individual genes and molecular mechanisms of the aging… (More)
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2008
2008
Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism.
Sirtuins are conserved proteins implicated in myriad key processes including gene control, aging, cell survival, metabolism, and… (More)
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2007
2007
SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.
The (Silent Information Regulator 2) Sir2 gene has been shown to regulate the life span of several model organisms. In mammals… (More)
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Highly Cited
2006
Highly Cited
2006
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.
Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD(+)-dependent deacetylases that modulate gene silencing, aging… (More)
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2006
2006
The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases.
The silent information regulator 2 (Sir2) family of NAD-dependent N-acetyl-protein deacetylases participates in the regulation of… (More)
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Highly Cited
2003
Highly Cited
2003
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases.
Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from… (More)
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Highly Cited
2003
Highly Cited
2003
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.
Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 1 and 2 (CTIP1 and CTIP2) enhance… (More)
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Highly Cited
2000
Highly Cited
2000
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological… (More)
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