NAD-Dependent Deacetylase Sirtuin-2

Known as: Silent Information Regulator 2, EC 3.5.1.-, SIR2-Like Protein 2 
NAD-dependent deacetylase sirtuin-2 (389 aa, ~43 kDa) is encoded by the human SIRT2 gene. This protein plays a role in the deacetylation of tubulin.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Papers overview

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2011
2011
The Sirtuin family of proteins (SIRT) encode a group of evolutionarily conserved, NAD-dependent histone deacetylases, involved in… (More)
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2009
2009
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information… (More)
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2009
2009
Aging research has developed rapidly over the past decade, identifying individual genes and molecular mechanisms of the aging… (More)
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2008
2008
Sirtuins are conserved proteins implicated in myriad key processes including gene control, aging, cell survival, metabolism, and… (More)
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2007
2007
The (Silent Information Regulator 2) Sir2 gene has been shown to regulate the life span of several model organisms. In mammals… (More)
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Highly Cited
2006
Highly Cited
2006
Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD(+)-dependent deacetylases that modulate gene silencing, aging… (More)
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2006
2006
The silent information regulator 2 (Sir2) family of NAD-dependent N-acetyl-protein deacetylases participates in the regulation of… (More)
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Highly Cited
2003
Highly Cited
2003
Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from… (More)
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Highly Cited
2003
Highly Cited
2003
Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 1 and 2 (CTIP1 and CTIP2) enhance… (More)
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Highly Cited
2000
Highly Cited
2000
Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological… (More)
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