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NAD-Dependent Deacetylase Sirtuin-2

Known as: Silent Information Regulator 2, EC 3.5.1.-, SIR2-Like Protein 2 
NAD-dependent deacetylase sirtuin-2 (389 aa, ~43 kDa) is encoded by the human SIRT2 gene. This protein plays a role in the deacetylation of tubulin.
National Institutes of Health

Related topics

Related topics

7 relations
Cell divisionCytoskeletonDeacetylationEnzyme Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Sirtuins as emerging anti-parasitic targets.
  • Weiping Zheng
  • European journal of medicinal chemistry
  • 2013
  • Corpus ID: 33728924
2012
2012
Anti-leishmanial activity of the bisnaphthalimidopropyl derivatives.
2011
2011
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Neuroblastoma Cells: Role of Sirtuin 1
Resveratrol prolongs lifespan and prevent cancer formation; however, the mechanisms are not understood. Here we evaluated the… 
2009
2009
Molecular cloning and characterization of porcine sirtuin genes.
2008
2008
Genomewide Screen for Negative Regulators of Sirtuin Activity in Saccharomyces cerevisiae Reveals 40 Loci and Links to Metabolism
Sirtuins are conserved proteins implicated in myriad key processes including gene control, aging, cell survival, metabolism, and… 
2007
2007
Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.
Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces… 
Highly Cited
2006
Highly Cited
2006
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
Sirtuin 6 (SIRT6) is a member of the sirtuin deacetylases (sirtuins), which are derivatives of the yeast Silent information… 
2006
2006
Caspase-mediated changes in Sir2alpha during apoptosis.
Silent information regulator 2 (Sir2) is an NAD(+)-dependent histone deacetylase that establishes repressive chromatin status and… 
Highly Cited
2005
Highly Cited
2005
Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.
1998
1998
Leishmania major: Cell type dependent distribution of a 43 kDa antigen related to silent information regulatory‐2 protein family
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