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Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival.
TLDR
The existence of a regulated cell death programme inducing an apoptotic phenotype in a unicellular eukaryote provides a paradigm for a widespread role for PCD in the control of cell survival, which extends beyond the evolutionary constraints that may be specific to multicellular organisms and raises the question of the origin and nature of the genes involved. Expand
SIR2-Deficient Leishmania infantum Induces a Defined IFN-γ/IL-10 Pattern That Correlates with Protection1
TLDR
It is proposed that the polarization to a high IFN-γ/low IL-10 ratio after challenge is a clear indicator of vaccine success and these mutants, which presented attenuated virulence, represent a good model to understand the correlatives of protection in visceral leishmaniasis. Expand
The Trypanosoma cruzi Tc52-Released Protein Induces Human Dendritic Cell Maturation, Signals Via Toll-Like Receptor 2, and Confers Protection Against Lethal Infection1
TLDR
It is reported that immunization with Tc52 protects mice in vivo against lethal infection with T. cruzi, and the immune protection data suggest that Tc 52 is among candidate molecules that may be used to design an optimal multicomponent vaccine to control T. cruiser infection. Expand
Antimonial-Mediated DNA Fragmentation inLeishmania infantum Amastigotes
TLDR
The results demonstrate that the antileishmanial toxicity of Sb(III) antimonials is associated with parasite oligonucleosomal DNA fragmentation, indicative of the occurrence of late events in the overall process of apoptosis. Expand
Histone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors
TLDR
The data support the notion that thelevel of cell sensitivity to the HDIs might be related to the level of expression of genes such as those encoding proteins playing a role in cell cycle checkpoints control but not HDAC per se. Expand
Axenically Grown Amastigotes of Leishmania infantum Used as an In Vitro Model To Investigate the Pentavalent Antimony Mode of Action
TLDR
Results were consistent with the hypothesis of an intramacrophagic metabolic conversion of Sb(V) into trivalent compounds, which in turn became readily toxic to the Leishmania amastigote stage. Expand
The Leishmania infantum cytosolic SIR2-related protein 1 (LiSIR2RP1) is an NAD+ -dependent deacetylase and ADP-ribosyltransferase.
TLDR
It is demonstrated that LiSIR2RP1 is an NAD(+)-dependent deacetylase that also exerts an ADP-ribosyltransferase activity and may have significant implications during the remodelling of the morphology of the parasite and its interaction with the host cell. Expand
Advances and perspectives in Leishmania cell based drug-screening procedures.
TLDR
This review will focus on available methodologies for direct drug screening purposes against the mammalian stage of the parasite, with emphasis on the future developments that could improve sensitivity, reliability, versatility and the throughput of the intracellular model screening. Expand
Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications.
TLDR
The determination of immunoglobulin (Ig) isotypes revealed high levels of total IgG in both symptomatic and asymptomatic animals when compared to IgM, and the IgG2 appeared to be the predominant subclass of Ig present in the sera of infected animals particularly in the case of symptomatic dogs. Expand
Live attenuated Leishmania vaccines: a potential strategic alternative
TLDR
Recent findings related to genetically defined live attenuated Leishmania parasites as promising vaccine candidates are reviewed. Expand
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