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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points. Expand
SIR2-Deficient Leishmania infantum Induces a Defined IFN-γ/IL-10 Pattern That Correlates with Protection1
TLDR
It is proposed that the polarization to a high IFN-γ/low IL-10 ratio after challenge is a clear indicator of vaccine success and these mutants, which presented attenuated virulence, represent a good model to understand the correlatives of protection in visceral leishmaniasis. Expand
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
TLDR
Evidence is shown that both enzymes are active as peroxidases in vivo and that they have complementary roles in parasite protection against oxidative stress. Expand
Regulation of immunity during visceral Leishmania infection
TLDR
A comprehensive understanding of the immune events that occur during visceral Leishmania infection is crucial for the implementation of immunotherapeutic approaches that complement the current anti-Leishmania chemotherapy and the development of effective vaccines to prevent disease. Expand
Proinflammatory Environment Dictates the IL-17–Producing Capacity of Human Invariant NKT Cells
TLDR
It is reported that human CD161+ iNKT cells are intrinsically endowed with the capacity to generate IL-17, but require TGF-β, IL-1β, and IL-23 to carry out this potential, which depends on two critical parameters, namely an intrinsic program and a proinflammatory environment. Expand
Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles.
TLDR
The association of HBsAg with the alginate coated chitosan nanoparticles, administered intranasally to the mice, gave rise to the humoral mucosal immune response and the generation of Th1-biased antigen-specific systemic antibodies was observed whenHBsAg loaded nanoparticles were applied together with a second adjuvant, the immunopotentiator, CpG ODN. Expand
Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion.
TLDR
It is suggested that LiTXN1 and Li TXN2 are part of two distinct antioxidant machineries, one cytosolic, the other mitochondrial, that complement each other to ensure effective defence from several sources of oxidants throughout the development of L. infantum. Expand
Prevalence of antibodies to Leishmania infantum and Toxoplasma gondii in horses from the north of Portugal
TLDR
Horses are exposed to and may be infected with L. infantum and T. gondii in the north of Portugal and both agents have zoonotic and economic importance. Expand
Application of an Improved Enzyme-Linked Immunosorbent Assay Method for Serological Diagnosis of Canine Leishmaniasis
TLDR
Overall, the obtained results showed that the strategy of combining two well-defined Leishmania antigens, LicTXNPx and rK39, proved to be a sensitive and specific improvement to current serological diagnosis of CanL, being a useful tool for the detection of both clinical and subclinical forms of canine Leishmaniasis. Expand
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
TLDR
The characterization of a parasite protein with B-cell mitogenic properties in culture supernatants of infective forms, the cloning of the corresponding gene and the analysis of the biological properties of its product show that its expression as a cytoplasmic and/or membrane-associated protein is life-stage specific. Expand
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