NAD(P)H dehydrogenase (quinone) 1, human

Known as: EC 1.6.5.2, Diaphorase-4, NQO1 
NAD(P)H dehydrogenase [quinone] 1 (274 aa, ~31 kDa) is encoded by the human NQO1 gene. This protein is involved in hydroquinone synthesis.
National Institutes of Health

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CRYZ geneEnzyme GeneFMN reductaseHypoxia Pathway
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NAD(P)H Dehydrogenase (Quinone)

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Highly Cited
2012
Highly Cited
2012
Energy Converting NADH : Quinone Oxidoreductase ( Complex I )
  • Ια, Ιγ, Ιβ
  • 2012
NADH:quinone oxidoreductase (complex I) pumps protons across the inner membrane of mitochondria or the plasma membrane of many… (More)
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Highly Cited
2004
Highly Cited
2004
NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.
Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully… (More)
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Review
2004
Review
2004
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix…
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of… (More)
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Review
2000
Review
2000
Regulation of genes encoding NAD(P)H:quinone oxidoreductases.
NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze two-electron… (More)
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Highly Cited
2000
Highly Cited
2000
NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity.
beta-Lapachone activates a novel apoptotic response in a number of cell lines. We demonstrate that the enzyme NAD(P)H:quinone… (More)
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Highly Cited
1997
Highly Cited
1997
The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant.
alpha-Tocopherolquinone (TQ), a product of alpha-tocopherol oxidation, can function as an antioxidant after reduction to alpha… (More)
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Highly Cited
1996
Highly Cited
1996
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.
Twenty-four base pairs of the human antioxidant response element (hARE) are required for high basal transcription of the NAD(P)H… (More)
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Highly Cited
1995
Highly Cited
1995
A phylogenetic analysis of the genus Nocardia with 16S rRNA gene sequences.
Partial sequences of the 16S rRNA genes of the type strains of nine species of the genus Nocardia were determined following the… (More)
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Highly Cited
1992
Highly Cited
1992
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
NAD(P)H:quinone oxidoreductase (DT-diaphorase; DTD) is an obligate two-electron reductase which may play a role in the… (More)
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Highly Cited
1981
Highly Cited
1981
Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implications.
  • Microbiological reviews
  • 1981
[This corrects the article on p. 318 in vol. 45.]. 
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