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Somatic mutations affect key pathways in lung adenocarcinoma
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborativeExpand
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Characterizing the cancer genome in lung adenocarcinoma
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematicExpand
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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smokingExpand
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Common 5p15.33 and 6p21.33 variants influence lung cancer risk
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1Expand
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Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.
Sequence variations have been identified in a number of DNA repair genes, including XPD, but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We therefore examined XPDExpand
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Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.
In humans the glutathione S-transferase (GST) genes encode four classes of proteins (GST) important in the detoxification of reactive electrophiles. Recently, a gene deletion polymorphism wasExpand
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A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not wellExpand
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A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
DNA repair is central to genomic integrity. Reduced expression of several nucleotide excision repair genes has been demonstrated to be associated with increased risk of lung cancer. BecauseExpand
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Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis.
BACKGROUND Insulin-like growth factors (IGFs), in particular IGF-I and IGF-II, strongly stimulate the proliferation of a variety of cancer cells, including those from lung cancer. To examine theExpand
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p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
  • X. Wu, H. Zhao, +5 authors M. Spitz
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 1 May 2002
BACKGROUND The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Mutations in p53 have been associated with inherited cancer susceptibility. Because there isExpand
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