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Short chain fatty acids in human large intestine, portal, hepatic and venous blood.
Data indicate that substantial carbohydrate, and possibly protein, fermentation is occurring in the human large intestine, principally in the caecum and ascending colon and that the large bowel may have a greater role to play in digestion than has previously been ascribed to it. Expand
The control and consequences of bacterial fermentation in the human colon.
Regulation of short-chain fatty acid production
Chemostat studies using pure cultures of saccharolytic gut micro-organisms demonstrate that C availability and growth rate strongly affect the outcome of fermentation, which can be seen through the effects of inorganic electron acceptors on fermentation processes. Expand
Comparison of fermentation reactions in different regions of the human colon.
Findings demonstrate significant differences in fermentation reactions in different regions of the large gut in two human sudden-death victims. Expand
Characterization of Bacterial Communities in Feces from Healthy Elderly Volunteers and Hospitalized Elderly Patients by Using Real-Time PCR and Effects of Antibiotic Treatment on the Fecal Microbiota
The numbers of enterobacteria increased in the hospitalized patients who did not receive antibiotics, and due to profound changes in fecal microbiotas during antibiotic treatment, the opportunistic species Enterococcus faecalis proliferated. Expand
Validation of a Three-Stage Compound Continuous Culture System for Investigating the Effect of Retention Time on the Ecology and Metabolism of Bacteria in the Human Colon
Correlations between in vivo chemical and bacteriological measurements and data obtained in vitro demonstrate that the three-stage fermentation system provided a useful model for studying the physiology and ecology of large intestinal microorganisms under different nutritional and environmental conditions. Expand
Bacterial metabolism and health‐related effects of galacto‐oligosaccharides and other prebiotics
Most studies involving prebiotic oligosaccharides have been carried out using inulin and its fructo‐oligosaccharide (FOS) derivatives, together with various forms of galacto‐oligosaccharides (GOS).Expand
Prebiotic digestion and fermentation.
Present evidence concerning the 2 most studied prebiotics, fructooligosaccharides and inulin, is consistent with their resisting digestion by gastric acid and pancreatic enzymes in vivo, but the wide variety of new candidate prebiotic becoming available for human use requires that a manageable set of in vitro tests be agreed on. Expand
Bacteria, colonic fermentation, and gastrointestinal health.
As digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel. Expand