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N(7)-hydroxyethylguanine

Known as: 7-(2-hydroxyethyl)guanine, N7-(2-hydroxyethyl)guanine 
National Institutes of Health

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2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation.
Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of… 
Highly Cited
2005
Highly Cited
2005
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.
2005
2005
Measurement of N7-(2'-hydroxyethyl)guanine in human DNA by gas chromatography electron capture mass spectrometry.
  • C. KaoR. Giese
  • Chemical Research in Toxicology
  • 2005
  • Corpus ID: 28434019
An improved method is presented, based on gas chromatography-electron capture mass spectrometry (GC-EC-MS), for measuring N7-(2… 
Review
2000
Review
2000
Carcinogenicity and Genotoxicity of Ethylene Oxide: New Aspects and Recent Advances
  • H. Bolt
  • Critical Reviews in Toxicology
  • 2000
  • Corpus ID: 21154564
ABSTRACT Long-term inhalation studies in rodents have presented unequivocal evidence of experimental carcinogenicity of ethylene… 
2000
2000
Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment.
1999
1999
A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its…
A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry (GC/EC/NCI-HRMS) method was… 
1999
1999
Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents.
The formation of N7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated previously in target and non-target tissues of F-344… 
1997
1997
A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxyethyl)guanine in DNA from human blood
Abstract A newly developed high-performance liquid chromatography (HPLC) method involves derivatization with phenylglyoxal and… 
1993
1993
Chemical synthesis and detection of the cross-link 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea.
We have synthesized 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane and confirmed its structure by ultraviolet and… 
Highly Cited
1992
Highly Cited
1992
Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice.
The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice… 
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