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N(7)-hydroxyethylguanine

Known as: 7-(2-hydroxyethyl)guanine, N7-(2-hydroxyethyl)guanine 
National Institutes of Health

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2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

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2014
2014
Ethylene oxide and propylene oxide derived N7-alkylguanine adducts are bypassed accurately in vivo.
2009
2009
DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response
This study has investigated if individual DNA adducts formed in human glioma cells treated with 3H-1-(2-chloroethyl)-1… 
2007
2007
DNA adducts in granulocytes of hospital workers exposed to ethylene oxide.
BACKGROUND Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen… 
2005
2005
The carcinogenic significance of reactive intermediates derived from 3-acetoxy- and 5-acetoxy-2-hydroxy-N-nitrosomorpholine.
N-Nitroso-2-hydroxymorpholine (NHMOR), a relatively reactive metabolite of two potent carcinogens, N-nitrosodiethanolamine (NDELA… 
1999
1999
Comparison of (32)P-postlabeling and high-resolution GC/MS in quantifying N7-(2-Hydroxyethyl)guanine adducts.
This study compares (32)P-postlabeling and high-resolution gas chromatography/mass spectrometry (GC/MS) in the quantification of… 
1997
1997
High-performance liquid chromatography/electrospray mass spectrometry for the analysis of modified bases in DNA: 7-(2-hydroxyethyl)guanine, the major ethylene oxide-DNA adduct.
A method was developed for the analysis of 7-(2-hydroxyethyl)guanine (7HEG), the major DNA adduct formed after exposure to… 
1992
1992
Activation of a beta-hydroxyalkylnitrosamine to alkylating agents: evidence for the involvement of a sulfotransferase.
N-Nitrosomethyl(2-hydroxyethyl)amine (NMHEA), when administered by gavage, is a strong liver carcinogen in F344 female rats, but… 
1991
1991
Release of 7-alkylguanines from N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea-modified DNA by 3-methyladenine DNA glycosylase II.
Purified bacterial 3-methyladenine DNA glycosylase II releases four 7-alkylguanines from [3H]N-(2-chloroethyl)-N'-cyclohexyl-N… 
1990
1990
Preparation of electrophoric derivatives of N7-(2-hydroxyethyl)guanine, an ethylene oxide DNA adduct.
1986
1986
Modification of DNA and metabolism of ethyl carbamate in vivo: formation of 7-(2-oxoethyl)guanine and its sensitive determination by reductive tritiation using 3H-sodium borohydride.
The modification of liver DNA of mice and rats by ethyl carbamate and its putative proximate metabolite, vinyl carbamate, has… 
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