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N(7)-hydroxyethylguanine
Known as:
7-(2-hydroxyethyl)guanine
, N7-(2-hydroxyethyl)guanine
National Institutes of Health
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Related topics
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2 relations
Broader (1)
Guanine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation.
Debbie A Marsden
,
Donald J L Jones
,
+5 authors
K. Brown
Cancer Research
2009
Corpus ID: 21624494
Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of…
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Highly Cited
2005
Highly Cited
2005
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.
I. Rusyn
,
S. Asakura
,
+5 authors
J. Swenberg
DNA Repair
2005
Corpus ID: 5809354
2005
2005
Measurement of N7-(2'-hydroxyethyl)guanine in human DNA by gas chromatography electron capture mass spectrometry.
C. Kao
,
R. Giese
Chemical Research in Toxicology
2005
Corpus ID: 28434019
An improved method is presented, based on gas chromatography-electron capture mass spectrometry (GC-EC-MS), for measuring N7-(2…
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Review
2000
Review
2000
Carcinogenicity and Genotoxicity of Ethylene Oxide: New Aspects and Recent Advances
H. Bolt
Critical Reviews in Toxicology
2000
Corpus ID: 21154564
ABSTRACT Long-term inhalation studies in rodents have presented unequivocal evidence of experimental carcinogenicity of ethylene…
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2000
2000
Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment.
N. J. van Sittert
,
P. Boogaard
,
A. Natarajan
,
A. Tates
,
L. Ehrenberg
,
M. Törnqvist
Mutation research
2000
Corpus ID: 31424265
1999
1999
A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its…
K. Wu
,
N. Scheller
,
+4 authors
J. Swenberg
Chemical Research in Toxicology
1999
Corpus ID: 39034725
A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry (GC/EC/NCI-HRMS) method was…
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1999
1999
Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents.
K. Wu
,
A. Ranasinghe
,
P. Upton
,
V. Walker
,
J. Swenberg
Carcinogenesis
1999
Corpus ID: 15136142
The formation of N7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated previously in target and non-target tissues of F-344…
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1997
1997
A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxyethyl)guanine in DNA from human blood
H. Bolt
,
M. Leutbecher
,
K. Golka
Archives of Toxicology
1997
Corpus ID: 46278715
Abstract A newly developed high-performance liquid chromatography (HPLC) method involves derivatization with phenylglyoxal and…
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1993
1993
Chemical synthesis and detection of the cross-link 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea.
W. Bodell
,
K. Pongracz
Chemical Research in Toxicology
1993
Corpus ID: 42997816
We have synthesized 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane and confirmed its structure by ultraviolet and…
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Highly Cited
1992
Highly Cited
1992
Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice.
V. Walker
,
T. Fennell
,
+4 authors
J. Swenberg
Cancer Research
1992
Corpus ID: 14402373
The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice…
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