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The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.
We have investigated the presence of mutations in ras genes at codons 12, 13 and 61 in chemically induced pancreatic tumors of rats and Syrian hamsters. Mutations were detected by means of… Expand
Simple Measurement of Captopril in Plasma by High‐Performance Liquid Chromatography with Ultraviolet Detection
- J. Klein, P. Colin, E. Scherer, M. Levy, G. Koren
- Chemistry, Medicine
- Therapeutic drug monitoring
- 1 January 1990
Captopril is an orally active inhibitor of angiotensin-converting enzyme. A rapid, accurate, and sensitive high-performance chromatography (HPLC) method is described for measuring plasma… Expand
Kinetics of formation of O6-ethylguanine in, and its removal from liver DNA of rats receiving diethylnitrosamine.
Abstract The ethylation of rat liver DNA by a single dose of diethylnitrosamine and the stability of O6-ethylguanine in vivo were studied. Whereas the dose response relations for 7-ethylguanine,… Expand
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
Abstract Previous findings showed that a single dose of 10–20 mg diethylnitrosamine/kg rat induced foci of atypical liver cells (islands) which might qualify as tumor cell precursors since they… Expand
Quantitative study on foci of altered liver cells induced in the rat by a single dose of diethylnitrosamine and partial hepatectomy.
Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays.
Antibodies raised in rabbits against the bovine serum albumin conjugates of O6-ethylguanosine and N-(guanosin-8-yl)-N-acetyl-2-aminofluorene have been used to develop a high-sensitive enzyme-linked… Expand
Formation by diethylnitrosamine and persistence of O4-ethylthymidine in rat liver DNA in vivo.
The formation by diethylnitrosamine (DEN) and persistence of O4-ethylthymidine in rat liver DNA in vivo has been studied using enzymic hydrolysis of DNA, cation exchange column chromatography and… Expand
Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions.
On the basis of the multi-hit concept of cancer formation, the relationships between tumor incidence and dose and time of administration of carcinogen have been analyzed. Simple mathematics have been… Expand
Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections.
- P. Terheggen, B. Floot, E. Scherer, A. Begg, A. M. Fichtinger-Schepman, L. den Engelse
- Biology, Medicine
- Cancer research
- 15 December 1987
Calf thymus DNA was modified in vitro by cis-diamminedichloroplatinum(II) (cisDDP), complexed with methylated bovine serum albumin and used to immunize rabbits. The anti-cisDDP-DNA antiserum obtained… Expand