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DNA methylation arrays as surrogate measures of cell mixture distribution
We present a method, similar to regression calibration, for inferring changes in the distribution of white blood cells between different subpopulations (e.g. cases and controls) using DNA methylation signatures, in combination with an external validation set consisting of signatures from purified leukocyte samples. Expand
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Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
BACKGROUND The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five gliomaExpand
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Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked toExpand
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Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.
In humans the glutathione S-transferase (GST) genes encode four classes of proteins (GST) important in the detoxification of reactive electrophiles. Recently, a gene deletion polymorphism wasExpand
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The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
A mutant promoter's partner in crime Telomerase is an enzyme that maintains the ends of chromosomes. TERT, the gene coding for the enzyme's catalytic subunit, is not expressed in healthy somaticExpand
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The landscape of recombination in African Americans
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build aExpand
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Associations between Polymorphisms in DNA Repair Genes and Glioblastoma
A pooled analysis was conducted to examine the association between select variants in DNA repair genes and glioblastoma multiforme, the most common and deadliest form of adult brain tumors. GeneticExpand
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Variants in the CDKN2B and RTEL1 regions are associated with high grade glioma susceptibility
The causes of glioblastoma and other gliomas remain obscure. To discover new candidate genes influencing glioma susceptibility, we conducted a principal component–adjusted genome-wide associationExpand
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A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine theExpand
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Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.
Polymorphisms in several DNA repair genes have recently been identified, but little is known about their phenotypic significance. To determine whether variation in DNA repair genes is related to hostExpand
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