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- Publications
- Influence
Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases
- S. Fekairi, Sarah Scaglione, +10 authors Pierre-Henri L. Gaillard
- Biology, Medicine
- Cell
- 10 July 2009
Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5' flap endonuclease Slx1-Slx4 has received particular attention with the… Expand
The Y-family of DNA polymerases.
- H. Ohmori, E. Friedberg, +13 authors R. Woodgate
- Medicine, Biology
- Molecular cell
- 1 July 2001
We would like to thank Tomoo Ogi for generating the unrooted phylogenetic tree shown in Figure 1Figure 1 and Junetsu Ito for his comments on our proposal.
Trading places: how do DNA polymerases switch during translesion DNA synthesis?
- E. Friedberg, A. Lehmann, R. Fuchs
- Biology, Medicine
- Molecular cell
- 27 May 2005
The replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechanism for relieving arrested DNA replication. The process requires multiple polymerase switching… Expand
The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis.
In Escherichia coli, the dinB gene is required for the SOS-induced lambda untargeted mutagenesis pathway and confers a mutator phenotype to the cell when the gene product is overexpressed. Here, we… Expand
All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
- R. Napolitano, R. Janel-Bintz, J. Wagner, R. Fuchs
- Biology, Medicine
- The EMBO journal
- 15 November 2000
Most organisms contain several members of a recently discovered class of DNA polymerases (umuC/dinB superfamily) potentially involved in replication of damaged DNA. In Escherichia coli, only Pol V… Expand
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.
- A. Tissier, P. Kannouche, Marie-Pierre Reck, A. Lehmann, R. Fuchs, A. Cordonnier
- Medicine, Biology
- DNA repair
- 2 November 2004
The progress of replicative DNA polymerases along the replication fork may be impeded by the presence of lesions in the genome. One way to circumvent such hurdles involves the recruitment of… Expand
How DNA lesions are turned into mutations within cells?
Genomes of all living organisms are constantly injured by endogenous and exogenous agents that modify the chemical integrity of DNA and in turn challenge its informational content. Despite the… Expand
Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients
- B. Broughton, A. Cordonnier, +12 authors A. Lehmann
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 2 January 2002
Xeroderma pigmentosum variant (XP-V) cells are deficient in their ability to synthesize intact daughter DNA strands after UV irradiation. This deficiency results from mutations in the gene encoding… Expand
Structural and biochemical analysis of sliding clamp/ligand interactions suggest a competition between replicative and translesion DNA polymerases.
- D. Burnouf, V. Olieric, +4 authors P. Dumas
- Medicine, Biology
- Journal of molecular biology
- 30 January 2004
Most DNA polymerases interact with their cognate processive replication factor through a small peptide, this interaction being absolutely required for their function in vivo. We have solved the… Expand
The β clamp targets DNA polymerase IV to DNA and strongly increases its processivity
The recent discovery of a new family of ubiquitous DNA polymerases involved in translesion synthesis has shed new light onto the biochemical basis of mutagenesis. Among these polymerases, the dinB… Expand