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Nuclease P1 digestion/high-performance liquid chromatography, a practical method for DNA quantitation.
We have developed a practical method for quantifying DNA. The method is practical in two ways. First, a single enzyme is used to digest the DNA to nucleotides that are then quantified by HPLC underExpand
Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure.
Formaldehyde is an ubiquitous pollutant to which humans are exposed. Pathologists can experience high formaldehyde exposure levels. Formaldehyde-among other properties-induce oxidative stress andExpand
Measurement of free thyroid hormones in serum by dialysis and gas chromatography.
We describe a simultaneous, absolute analysis for free (dialyzable) triiodothyronine and thyroxine in serum by the sequence: dialysis, internal standard addition to the dialysate, cation-exchangeExpand
Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro.
Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes inExpand
Measurement of endogenous estrogens: analytical challenges and recent advances.
  • R. Giese
  • Chemistry, Medicine
  • Journal of chromatography. A
  • 6 June 2003
Recent developments in the analysis of endogenous estrogens (including both free and conjugated estrogens) are reviewed. Largely due to urging by some cancer researchers, new demands are now beingExpand
DNA adducts in granulocytes of hospital workers exposed to ethylene oxide.
BACKGROUND Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen. Occupational EtO exposure in many countries is regulated at 1 ppmExpand
Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers.
Tobacco smoke has been shown to produce both DNA damage and epigenetic alterations. However, the potential role of DNA damage in generating epigenetic changes is largely underinvestigated in humanExpand
Measuring DNA adducts by gas chromatography-electron capture-mass spectrometry: trace organic analysis.
Publisher Summary This chapter discusses the practical experience in method development for the determination of trace amounts of DNA adducts, by gas chromatography-electron capture-mass spectrometryExpand
Technical considerations in the use of "high-performance" liquid chromatography in therapeutic drug monitoring.
  • R. Giese
  • Chemistry, Medicine
  • Clinical chemistry
  • 1 July 1983
I review the methodology of "high-performance" liquid chromatography as applied to therapeutic drug monitoring. Aside from direct injection of sample, sample cleanup involves miscible and immiscibleExpand
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