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Multidrug Resistance-Associated Proteins

Known as: Multispecific Organic Anion Transporter, Multidrug Resistance-Associated Proteins [Chemical/Ingredient], Resistance-Associated Protein, Multidrug 
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion… 
National Institutes of Health

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Related topics

27 relations
ABCC1 geneABCC1 wt AlleleIn BloodMulti-Drug Resistance
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Narrower (14)

ABCC10 protein, humanABCC5 protein, humanABCC6 protein, humanAbcc4 protein, rat
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Papers overview

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Highly Cited
2002
Highly Cited
2002
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for… 
Review
2000
Review
2000
A family of drug transporters: the multidrug resistance-associated proteins.
The human multidrug resistance-associated protein (MRP) family currently has seven members. The ability of several of these… 
Highly Cited
1999
Highly Cited
1999
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.
The blood-brain barrier and a blood-cerebrospinal-fluid (CSF) barrier function together to isolate the brain from circulating… 
Highly Cited
1997
Highly Cited
1997
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the… 
Highly Cited
1997
Highly Cited
1997
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X… 
Highly Cited
1996
Highly Cited
1996
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
The human Dubin-Johnson syndrome and its animal model, the TR− rat, are characterized by a chronic conjugated hyperbilirubinemia… 
Highly Cited
1995
Highly Cited
1995
The drug resistance-related protein LRP is the human major vault protein
Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein… 
Highly Cited
1995
Highly Cited
1995
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.
The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance… 
Highly Cited
1994
Highly Cited
1994
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor… 
Highly Cited
1994
Highly Cited
1994
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.
Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been… 
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