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Multidrug Resistance-Associated Proteins

Known as: Multispecific Organic Anion Transporter, Multidrug Resistance-Associated Proteins [Chemical/Ingredient], Resistance-Associated Protein, Multidrug 
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion… (More)

Topic mentions per year

Topic mentions per year

1987-2017
05010015019872017

Related topics

Related topics

20 relations
ABCC1 geneABCC1 wt AlleleIn BloodMulti-Drug Resistance
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Narrower (5)

ABCC5 protein, humanABCC6 protein, humanMultidrug Resistance Associated Protein 1multidrug resistance-associated protein 2
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Multidrug Resistance-Associated Proteins
physiological aspects
agonists
Multi-Drug Resistance
chemical synthesis
Multidrug Resistance Gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
UNLABELLED Multidrug resistance-associated proteins (Mrps) are adenosine triphosphate-dependent transporters that efflux… (More)
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Highly Cited
2004
Highly Cited
2004
A multidrug resistance-associated protein involved in anthocyanin transport in Zea mays.
Anthocyanin biosynthesis is one of the most thoroughly studied enzymatic pathways in biology, but little is known about the… (More)
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Highly Cited
2002
Highly Cited
2002
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
1999
Highly Cited
1999
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.
The blood-brain barrier and a blood-cerebrospinal-fluid (CSF) barrier function together to isolate the brain from circulating… (More)
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Highly Cited
1999
Highly Cited
1999
Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study.
Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML). Such resistance has been associated… (More)
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Highly Cited
1999
Highly Cited
1999
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.
BACKGROUND Human cancer cell lines grown in the presence of the cytotoxic agent mitoxantrone frequently develop resistance… (More)
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Highly Cited
1997
Highly Cited
1997
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the… (More)
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Highly Cited
1997
Highly Cited
1997
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X… (More)
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Highly Cited
1994
Highly Cited
1994
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor… (More)
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Highly Cited
1994
Highly Cited
1994
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.
Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been… (More)
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