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Multidrug Resistance-Associated Proteins

Known as: Multispecific Organic Anion Transporter, Multidrug Resistance-Associated Proteins [Chemical/Ingredient], Resistance-Associated Protein, Multidrug 
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion… 
National Institutes of Health

Related topics

Related topics

27 relations
ABCC1 geneABCC1 wt AlleleIn BloodMulti-Drug Resistance

Narrower (14)

ABCC10 protein, humanABCC5 protein, humanABCC6 protein, humanAbcc4 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin.
The clinical success of anthracyclines-containing chemotherapy for breast cancer is mainly restricted by cardiac damage and the… 
2012
2012
A Mutation in Intracellular Loop 4 Affects the Drug-Efflux Activity of the Yeast Multidrug Resistance ABC Transporter Pdr5p
Multidrug resistance protein Pdr5p is a yeast ATP-binding cassette (ABC) transporter in the plasma membrane. It confers multidrug… 
Review
2011
Review
2011
Evolution of drug resistance in cancer: the emergence of unique mechanisms and novel techniques.
Dramatic decreases in the mortality rates due to both cardiovascular and cerebrovascular diseases have been reported over the… 
2010
2010
Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents.
A new series of 4 beta-anilino-podophyllotoxin analogs have been designed, synthesized and evaluated their bioactivities as novel… 
2002
2002
Modulating multidrug resistance: can we target this therapy?
The MDR[3][1] phenotype was developed by exposing cells to very high concentrations of cytotoxic agents in vitro [(1)][2] . The… 
1999
1999
Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia
In vitro resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL), but the… 
1999
1999
Cloning and Functional Characterization of a New Multispecific Organic Anion Transporter , OAT-K 2 , in Rat Kidney
We have isolated a cDNA coding a new organic anion transporter, OAT-K2, expressed specifically in rat kidney. The OAT-K2 cDNA had… 
1999
1999
Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins.
I (and a number of my colleagues both here and abroad) believe that many of the findings reported by Belinsky et al. (1) were… 
1998
1998
P-Glycoprotein Expression on Normal and Abnormally Expanded Natural Killer Cells and Inhibition of P-Glycoprotein Function by Cyclosporin A and Its Analogue , PSC 833
P-glycoprotein (P-gp), a transmembrane efflux pump encoded by the MDR1 gene, has been found to be expressed in many normal bone… 
Review
1996
Review
1996
Multidrug resistance-associated protein (MRP) in haematological malignancies.
The presence of multidrug resistant cells, either acquired or de novo, severely limits treatment outcome in haematological…