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Multidrug Resistance-Associated Proteins
Known as:
Multispecific Organic Anion Transporter
, Multidrug Resistance-Associated Proteins [Chemical/Ingredient]
, Resistance-Associated Protein, Multidrug
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A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion…
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National Institutes of Health
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Related topics
Related topics
27 relations
ABCC1 gene
ABCC1 wt Allele
In Blood
Multi-Drug Resistance
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Narrower (14)
ABCC10 protein, human
ABCC5 protein, human
ABCC6 protein, human
Abcc4 protein, rat
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
John D. Allen
,
A. van Loevezijn
,
+6 authors
A. Schinkel
Molecular cancer therapeutics
2002
Corpus ID: 5841313
Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for…
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Review
2000
Review
2000
A family of drug transporters: the multidrug resistance-associated proteins.
P. Borst
,
R. Evers
,
M. Kool
,
J. Wijnholds
Journal of the National Cancer Institute
2000
Corpus ID: 15836587
The human multidrug resistance-associated protein (MRP) family currently has seven members. The ability of several of these…
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Highly Cited
1999
Highly Cited
1999
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.
V. Rao
,
J. Dahlheimer
,
+4 authors
D. Piwnica-Worms
Proceedings of the National Academy of Sciences…
1999
Corpus ID: 25554670
The blood-brain barrier and a blood-cerebrospinal-fluid (CSF) barrier function together to isolate the brain from circulating…
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Highly Cited
1997
Highly Cited
1997
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
M. Kool
,
M. de Haas
,
+5 authors
P. Borst
Cancer research
1997
Corpus ID: 1001706
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the…
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Highly Cited
1997
Highly Cited
1997
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
J. Wijnholds
,
R. Evers
,
+7 authors
P. Borst
Nature Medicine
1997
Corpus ID: 23326400
The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X…
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Highly Cited
1996
Highly Cited
1996
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
C. Paulusma
,
P. Bosma
,
+6 authors
R. P. Elferink
Science
1996
Corpus ID: 42819554
The human Dubin-Johnson syndrome and its animal model, the TR− rat, are characterized by a chronic conjugated hyperbilirubinemia…
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Highly Cited
1995
Highly Cited
1995
The drug resistance-related protein LRP is the human major vault protein
G. Scheffer
,
P. Wijngaard
,
+6 authors
R. Scheper
Nature Medicine
1995
Corpus ID: 29771830
Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein…
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Highly Cited
1995
Highly Cited
1995
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.
V. Gekeler
,
W. Ise
,
K. Sanders
,
W. Ulrich
,
J. Beck
Biochemical and biophysical research…
1995
Corpus ID: 37790623
The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance…
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Highly Cited
1994
Highly Cited
1994
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
G. Zaman
,
M. Flens
,
+7 authors
H. Broxterman
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 262456
The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor…
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Highly Cited
1994
Highly Cited
1994
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.
C. Grant
,
G. Valdimarsson
,
D. Hipfner
,
K. Almquist
,
S. Cole
,
R. Deeley
Cancer research
1994
Corpus ID: 13017057
Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been…
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