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ABCC1 gene

Known as: ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 Gene, MRP1, MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 
This gene plays a role in multi-drug resistance and organic anion transport.
National Institutes of Health

Related topics

Related topics

10 relations
ABCC1 protein, humanDrug EffluxHomo sapiensLigand Binding

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ABCC1 wt Allele

Papers overview

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2016
2016
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.
Highly Cited
2010
Highly Cited
2010
Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel.
2008
2008
A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines
Inorganic arsenic trioxide (As2O3) is a highly effective treatment for acute promyelocytic leukemia (APL). However, other cancers… 
Highly Cited
2006
Highly Cited
2006
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines.
2006
2006
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
OBJECTIVE To explore the onset and molecular mechanism of resistance to the antimalarial disease-modifying antirheumatic drug… 
Highly Cited
2005
Highly Cited
2005
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo
Objectives The human immunodeficiency virus protease inhibitor nelfinavir is substrate of polyspecific drug transporters encoded… 
2002
2002
GSH-dependent Photolabeling of Multidrug Resistance Protein MRP1 (ABCC1) by [125I]LY475776
Substrates transported by the 190-kDa multidrug resistance protein 1 (MRP1) (ABCC1) include endogenous organic anions such as the… 
Highly Cited
2001
Highly Cited
2001
Identification of a Nonconserved Amino Acid Residue in Multidrug Resistance Protein 1 Important for Determining Substrate Specificity
Murine multidrug resistance protein 1 (mrp1), differs from its human ortholog (MRP1) in that it fails to confer anthracycline… 
1999
1999
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines
With the growing understanding of cytostatic drug-induced programmed cell death new drug-resistance mechanisms based on the… 
1999
1999
MRP 3 , an organic anion transporter able to transport anti-cancer drugs ( multidrug resistance y methotrexate y etoposide )
The human multidrug-resistance protein (MRP) gene family contains at least six members: MRP1, encoding the multidrug-resistance… 
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