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ABCC1 protein, human

Known as: ATP-Binding Cassette Sub-Family C Member 1, Multidrug Resistance-Associated Protein 1, ATP-binding cassette, sub-family C (CFTR-MRP), member 1, human 
Multidrug resistance-associated protein 1 (1531 aa, ~172 kDa) is encoded by the human ABCC1 gene. This protein plays a role in the cellular export of… 
National Institutes of Health

Related topics

Related topics

19 relations
ABCC1 geneAdenosine TriphosphatasesCellular MembraneDrug Efflux

Broader (1)

Multidrug Resistance Associated Protein 1

Papers overview

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2019
2019
5‐Oxo‐hexahydroquinoline derivatives as modulators of P‐gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells
Highly Cited
2012
Highly Cited
2012
Liver X Receptor Activation Enhances Blood–Brain Barrier Integrity in the Ischemic Brain and Increases the Abundance of ATP‐Binding Cassette Transporters ABCB1 and ABCC1 on Brain Capillary Cells
The blood–brain barrier (BBB) consists of dense contacts between endothelial cells, the tight junctions, which are complemented… 
Highly Cited
2010
Highly Cited
2010
Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies
ABSTRACTPurposeTo determine if solid lipid nanoparticles represent a viable strategy for local delivery of poorly water soluble… 
Highly Cited
2007
Highly Cited
2007
Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress.
Highly Cited
2006
Highly Cited
2006
Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1
Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron (Fe… 
Highly Cited
2004
Highly Cited
2004
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1).
Unconjugated bilirubin (UCB) causes encephalopathy in severely jaundiced neonates by damaging astrocytes and neurons. Astrocytes… 
Highly Cited
2004
Highly Cited
2004
Molecular Modeling Correctly Predicts the Functional Importance of Phe594 in Transmembrane Helix 11 of the Multidrug Resistance Protein, MRP1 (ABCC1)*
The human ATP-binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), confers resistance to a broad… 
Highly Cited
2001
Highly Cited
2001
Identification of an Amino Acid Residue in Multidrug Resistance Protein 1 Critical for Conferring Resistance to Anthracyclines*
Murine multidrug resistance protein 1 (mrp1), unlike human MRP1, does not confer resistance to anthracyclines. Previously, we… 
Highly Cited
2000
Highly Cited
2000
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1).
The mechanisms of MRP1-drug binding and transport are not clear. In this study, we have characterized the interaction between… 
Highly Cited
1999
Highly Cited
1999
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian…
Intrinsic and/or acquired resistance to chemotherapy is the major obstacle to overcome in the treatment of patients with ovarian… 
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