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ABCC5 protein, human

Known as: ATP-binding cassette, sub-family C (CFTR-MRP), member 5 protein, human, MRP5 transport protein, human, pABC11 protein, human 
Multidrug resistance-associated protein 5 (1437 aa, ~161 kDa) is encoded by the human ABCC5 gene. This protein plays a role in the export of cyclic… 
National Institutes of Health

Related topics

Related topics

19 relations
ABCC5 geneABCC5 wt AlleleAdenosine TriphosphatasesCellular Membrane

Broader (1)

Multidrug Resistance-Associated Proteins

Papers overview

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Highly Cited
2017
Highly Cited
2017
microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer.
Review
2016
Review
2016
Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity
Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and remains an important limitation of anthracycline… 
Highly Cited
2014
Highly Cited
2014
Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters
Recent studies have reported that hyper-methylation in the promoter region of miRNAs could silence the expression of tumor… 
Highly Cited
2011
Highly Cited
2011
Reduced miR-128 in Breast Tumor–Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5
Purpose: Tumor-initiating cells are resistant to chemotherapy, but how microRNAs play a role in regulating drug resistance of… 
Highly Cited
2009
Highly Cited
2009
Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters modulate the transport and metabolism of both… 
Review
2008
Review
2008
SMRP and HE4 as biomarkers for ovarian carcinoma when used alone and in combination with CA125 and/or each other.
Assays measuring SMRP (mesothelin) and HE4 (a secreted protease) in serum and other body fluids (including urine for SMRP) are… 
Review
2006
Review
2006
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Highly Cited
2006
Highly Cited
2006
Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients
SummaryDrug resistance is a major obstacle to the successful chemotherapy. Several ATP-binding cassette (ABC) transporters… 
Highly Cited
2006
Highly Cited
2006
Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
Review
2005
Review
2005
Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5)
Like other members of the multidrug resistance protein (MRP)/ABCC subfamily of ATP-binding cassette transporters, MRP4 (ABCC4… 
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