Morphine

Known as: Morphia, (-)-morphine, Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)- 
An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
CMAJ | MAY 8, 2017 | VOLUME 189 | ISSUE 18 E659 C hronic noncancer pain includes any painful condition that persists for at least… (More)
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Highly Cited
2001
Highly Cited
2001
An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Rapid development of acute opioid tolerance is well established in animals and is more likely to occur with large… (More)
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Highly Cited
1999
Highly Cited
1999
The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine nucleotide binding protein (G protein… (More)
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Highly Cited
1996
Highly Cited
1996
DESPITE tremendous efforts in the search for safe, efficacious and non-addictive opioids for pain treatment, morphine remains the… (More)
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Review
1995
Review
1995
Over the last several years, compelling evidence has accumulated indicating that central hyperactive states resulting from… (More)
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Highly Cited
1995
Highly Cited
1995
The nucleus accumbens is considered a critical target of the action of drugs of abuse. In this nucleus a "shell" and a "core… (More)
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Highly Cited
1987
Highly Cited
1987
A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses… (More)
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Highly Cited
1977
Highly Cited
1977
A method for assessing pain and analgesia in rats and cats is described. The procedure involves subcutaneous injection of dilute… (More)
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Highly Cited
1976
Highly Cited
1976
Three different syndromes produced by congeners of morphine have been identified in the nondependent chronic spinal dog. These… (More)
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