• Publications
  • Influence
Dynamics of drug dependence. Implications of a conditioning theory for research and treatment.
  • A. Wikler
  • Psychology, Biology
    Archives of general psychiatry
  • 1 May 1973
TLDR
To prevent relapse, both conditioned CCCs (conditioned abstinence, CA) and conditioned SAPD should be actively extinguished after DTX by elicitation of CA and programmed SAPD under conditions preventing pharmacological reinforcement.
Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and “relapse” in morphine-addicted rats
TLDR
The pre-potent factor in disposing to relapse, at least in the rat under the experimental conditions described, is the long-term persistence of unconditioned disturbances in homeostasis following with-drawal of morphine which can provide a source of reinforcement for operant conditioning of opioid-seeking behavior during “relapse-testing” sessions even without benefit of previous “training”.
Cross tolerance between LSD and psilocybin
TLDR
The development of “cross” tolerance between LSD and psilocybin reinforces the idea that these two drugs cause psychic disturbances by acting on some common mechanism, or on mechanisms acting through a common final pathway.
The first drink: psychobiological aspects of craving.
TLDR
It appeared that a sufficient amount of alcohol, administered in the context of explicit drinking cues, could act much like hors d'oeuvres and thereby contribute to the "first drink" relapse phenomenon.
"Craving" and relapse to drink.
  • A. Ludwig, A. Wikler
  • Psychology, Medicine
    Quarterly journal of studies on alcohol
  • 1 March 1974
It is hypothesized that the phenomenon of "craving" for alcohol represents a psychological or cognitive correlate of a subclinical conditioned withdrawal syndrome which may be evoked by any state o...
Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication.
TLDR
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe, Great Britain and the United States and are apparently the most effective and safest agent for inducing an experimental, but reversible, psychosis in nonpsychotic subjects.
Tolerance to and physical dependence on morphine in rats
TLDR
The secondary abstinence syndrome of rats addicted to large doses of morphine is protracted and small differences have been seen between addicted and control animals as long as four to six months after withdrawal of morphine.
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