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Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from… Expand Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a… Expand The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite… Expand The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… Expand Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase cascades in their repertoire of… Expand Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen… Expand PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… Expand The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… Expand AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The… Expand We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner… Expand