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A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus. Uganda-Case Western Reserve University Research Collaboration.
- C. Whalen, J. Johnson, +5 authors J. Ellner
- The New England journal of medicine
- 18 September 1997
A six-month course of isoniazid confers short-term protection against tuberculosis among PPD-positive, HIV-infected adults and multidrug regimens with isoniaZid and rifampin taken for three months also reduce the risk of tuberculosis. Expand
Accelerated course of human immunodeficiency virus infection after tuberculosis.
- C. Whalen, C. Horsburgh, D. Hom, C. Lahart, M. Simberkoff, J. Ellner
- American journal of respiratory and critical care…
Although active tuberculosis may be an independent marker of advanced immunosuppression in HIV-infected patients, it may also act as a cofactor to accelerate the clinical course of HIV infection. Expand
Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study
For tuberculosis case detection, sensitivity ofXpert Ultra was superior to that of Xpert in Patients with paucibacillary disease and in patients with HIV, however, this increase in sensitivity came at the expense of a decrease in specificity. Expand
Complement receptor-mediated uptake and tumor necrosis factor-alpha-mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages.
The data suggest that AM may play a prominent and efficient role in the primary defense of the lung in tuberculosis through CR-mediated uptake, predominantly CR4, and TNF-alpha-mediated killing of MTB. Expand
Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.
- C. Hirsch, R. Hussain, Z. Toossi, Ghaffar Dawood, F. Shahid, J. Ellner
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 April 1996
TGF-beta, produced in response to MTB antigens, plays a prominent role in down-regulating potentially protective host effector mechanisms and looms as an important mediator of immunosuppression in TB. Expand
Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis.
- K. Dahl, H. Shiratsuchi, B. Hamilton, J. Ellner, Z. Toossi
- Biology, Medicine
- Infection and immunity
- 1 February 1996
The extensive mannosyl capping of arabinose termini of ManLAM may underlie the lack of ability to induce some cytokines (IL-1, TNF-alpha, and IL-10) and the retained ability to induced TGF-beta, which may have a role in shifting the cytokine milieu in favor of survival of M. tuberculosis. Expand
Influence of tuberculosis on human immunodeficiency virus (HIV-1): enhanced cytokine expression and elevated beta 2-microglobulin in HIV-1-associated tuberculosis.
Observations suggest that HIV-1-associated tuberculosis is accompanied by immune activation that may result in increased HIV expression and accelerated progression to AIDS. Expand
Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.
Excess activity of this cytokine in blood monocytes may underlie the depressed T cell responses of patients with tuberculosis and within the infected tissues excess TGF-beta activity may interfere with anti-mycobacterial mechanisms and effective granuloma formation. Expand
Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: requirement for CD4+ T cells in purified protein derivative-positive, but not in…
These studies indicate that protective human recall responses to M. tb are mediated primarily by CD4+ T cells, whereas CD4-CD8- lymphocytes may contribute to innate immunity to M . Expand
Impact of pulmonary tuberculosis on survival of HIV-infected adults: a prospective epidemiologic study in Uganda
The findings from this prospective study indicate that active tuberculosis exerts its greatest effect on survival in the early stages of HIV infection, when there is a reserve capacity of the host immune response. Expand