Mitogen-Activated Protein Kinase 14

Known as: MAPK14 Mitogen Activated Protein Kinase, MAP Kinase, p38alpha, MAX Interacting Protein 2 
A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular… (More)
National Institutes of Health

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In BloodMAP3K8 protein, humanMAPK14 geneMAPK14 wt Allele
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
BACKGROUND PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor gene implicated in a wide… (More)
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Highly Cited
2004
Highly Cited
2004
TAB3, a new binding partner of the protein kinase TAK1.
We have identified a new binding partner of the TGFbeta (transforming growth factor-beta)-activated protein kinase (TAK1), termed… (More)
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Highly Cited
2003
Highly Cited
2003
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.
TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro. TAB1 became… (More)
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Highly Cited
1998
Highly Cited
1998
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.
BACKGROUND Specific inhibitors of protein kinases have great therapeutic potential, but the molecular basis underlying their… (More)
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1998
1998
Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1.
Overexpression of the protein kinases mixed-lineage kinase-2 (MLK2) or mitogen-activated protein kinase (MAPK) kinase kinase-1… (More)
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Highly Cited
1997
Highly Cited
1997
Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.
We have studied the phosphorylation of the Bcl-2 family of proteins by different mitogen-activated protein (MAP) kinases… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
A cDNA was cloned that encodes human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino acid… (More)
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Highly Cited
1997
Highly Cited
1997
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
The paired helical filament, which comprises the major fibrous element of the neurofibrillary lesions of Alzheimer's disease, is… (More)
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1997
1997
Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4.
Extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), and p38/RK/CSBP… (More)
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Highly Cited
1996
Highly Cited
1996
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.
The mitogen-activated protein (MAP) kinase family includes extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase… (More)
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