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Signal Transduction by the JNK Group of MAP Kinases
  • R. Davis
  • Medicine, Biology
  • Cell
  • 13 October 2000
MAP kinases are evolutionarily conserved proteins that are activated by a protein kinase cascade, including a MAP kinase kinase kinase, which phosphorylates a MAP kinase kinase, which in turnExpand
  • 3,975
  • 251
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Apoptosis plays an important role during neuronal development, and defects in apoptosis may underlie various neurodegenerative disorders. To characterize molecular mechanisms that regulate neuronalExpand
  • 4,942
  • 173
Transcription factor ATF2 regulation by the JNK signal transduction pathway
Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to beExpand
  • 1,243
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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
Abstract Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wideExpand
  • 1,485
  • 98
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
The ultraviolet (UV) response of mammalian cells is characterized by a rapid and selective increase in gene expression mediated by AP-1 and NF-kappa B. The effect on AP-1 transcriptional activityExpand
  • 2,580
  • 97
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growthExpand
  • 2,051
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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress. The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this cytoprotection. WeExpand
  • 1,795
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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms areExpand
  • 1,293
  • 73
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. The detection of p38 MAP kinase in the nucleus ofExpand
  • 1,174
  • 71
MAP kinases in the immune response.
MAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mammalian species, MAP kinases are involved in allExpand
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