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Candidate drugs against SARS-CoV-2 and COVID-19
Abstract Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future,Expand
Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.
UNLABELLED PHARMACOLOGICAL RELEVANCE: Presentation of the scratch assay as a convenient and inexpensive in vitro tool to gain first insights in the wound healing potential of plant extracts andExpand
PGE2 in the regulation of programmed erythrocyte death
Hyperosmotic shock, energy depletion, or removal of extracellular Cl− activates Ca2+-permeable cation channels in erythrocyte membranes. Subsequent Ca2+ entry induces erythrocyte shrinkage andExpand
Structural approaches to explain the selectivity of COX-2 inhibitors: is there a common pharmacophore?
The identification and characterisation of the isoenzyme cyclooxygenase 2 (COX-2) stimulated investigations to develop efficient non-steroidal anti-inflammatory drugs with reduced side effectsExpand
Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis.
Glycogen synthase kinase-3 (GSK-3) is known to modulate cell survival and apoptosis through multiple intracellular signaling pathways. However, its hepatoprotective function and its role inExpand
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
Objective: In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison with naproxen in patients with knee osteoarthritis (OA), using MRI andExpand
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
A novel class of nonantioxidant dual inhibitors of both CO and 5-LO is described. The balance between the activity against CO and 5-LO can be shifted by modifying the substitution pattern of theExpand
Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection
BackgroundBreast cancer belongs to the most frequent and severe cancer types in human. Since excretion of modified nucleosides from increased RNA metabolism has been proposed as a potential target inExpand
Inhibitors of c-Jun N-terminal kinases: an update.
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed.Expand
Progress towards a public chemogenomic set for protein kinases and a call for contributions
Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We haveExpand