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MAPK14 wt Allele

Known as: Mitogen-Activated Protein Kinase 14 wt Allele, PRKM14, PRKM15 
Human MAPK14 wild-type allele is located within 6p21.3-p21.2 and is approximately 83 kb in length. This allele, which encodes mitogen-activated… 
National Institutes of Health

Related topics

Related topics

35 relations
6p21.3-p21.2ApoptosisB Cell Receptor Signaling PathwayB-Cell Immune Response Pathway

Broader (1)

MAPK14 gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP
Autophagy, a lysosomal degradation pathway, is essential for homeostasis, development, neurological diseases, and cancer… 
Highly Cited
2007
Highly Cited
2007
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.
p38alpha is a stress-activated protein kinase that negatively regulates malignant transformation induced by oncogenic H-Ras… 
Highly Cited
2005
Highly Cited
2005
Phosphorylation of EEA1 by p38 MAP kinase regulates μ opioid receptor endocytosis
Morphine analgesic properties and side effects such as tolerance are mediated by the μ opioid receptor (MOR) whose endocytosis is… 
Highly Cited
2003
Highly Cited
2003
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38α at Ser423, Thr431 and Ser438 in vitro. TAB1 became… 
Highly Cited
2002
Highly Cited
2002
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP‐K2 and its interaction with cytokine mRNAs
Lipopolysaccharide (LPS) stimulates production of inflammatory mediators, partly by stabilizing [interleukin‐6 (IL‐6… 
Highly Cited
2002
Highly Cited
2002
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Phosphorylation of mitogen-activated protein kinases (MAPKs) on specific tyrosine and threonine sites by MAP kinase kinases… 
Highly Cited
2002
Highly Cited
2002
ERK5 MAPK Regulates Embryonic Angiogenesis and Acts as a Hypoxia-sensitive Repressor of Vascular Endothelial Growth Factor Expression*
During angiogenesis, endothelial cells undergo proliferation, reorganization, and stabilization to establish a mature vascular… 
Highly Cited
2000
Highly Cited
2000
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.
The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB… 
Highly Cited
1999
Highly Cited
1999
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.
Activation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal transduction via sequential… 
Highly Cited
1999
Highly Cited
1999
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.
Four p38 mitogen-activated protein kinases (p38alpha, beta, gamma, delta) have been described. To understand the role of p38… 
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