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Mice, Knockout

Known as: Mice, Knock-out, Knockout Mice, Knock-out Mice 
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology… 
National Institutes of Health

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Related topics

9 relations
Animals, Genetically ModifiedAnimals, TransgenicGene Knockout TechniquesGene Targeting

Papers overview

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Highly Cited
2010
Highly Cited
2010
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.
Numerous publications have described the importance of bone morphogenetic protein (BMP) signaling in the specification of… 
Highly Cited
2009
Highly Cited
2009
Lack of Cytochrome c in Mouse Fibroblasts Disrupts Assembly/Stability of Respiratory Complexes I and IV*
Cytochrome c (cyt c) is a heme-containing protein that participates in electron transport in the respiratory chain and as a… 
Highly Cited
2008
Highly Cited
2008
Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells
Highly Cited
2006
Highly Cited
2006
An Efficient Method for the Derivation of Mouse Embryonic Stem Cells
Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers; however, the process of ESC derivation is often… 
Highly Cited
2005
Highly Cited
2005
PPARγ in endothelial cells influences high fat diet-induced hypertension
Highly Cited
2005
Highly Cited
2005
The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen.
The activation function-1 (AF-1) domain of the estrogen receptor alpha (ERalpha) in stromal cells has been shown to be required… 
Highly Cited
2002
Highly Cited
2002
Mortality in 7B2 null mice can be rescued by adrenalectomy: Involvement of dopamine in ACTH hypersecretion
The serine protease prohormone convertase 2 (PC2), principally involved in the processing of polypeptide hormone precursors in… 
Highly Cited
2001
Highly Cited
2001
Tissue distribution of products of the mouse decay‐accelerating factor (DAF) genes. Exploitation of a Daf1 knock‐out mouse and site‐specific monoclonal antibodies
Decay‐accelerating factor (DAF) is a membrane regulator of C3 activation that protects self cells from autologous complement… 
Highly Cited
1999
Highly Cited
1999
Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice.
There are five known subtypes of muscarinic receptors (M(1)-M(5)). We have used knockout mice lacking the M(1), M(2), or M(4… 
Highly Cited
1999
Highly Cited
1999
Construction of Gene Targeting Vectors from λKOS Genomic Libraries
We describe a highly redundant murine genomic library in a new λ phage, λ knockout shuttle (λKOS) that facilitates the very rapid… 
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