Mice, Knockout

Known as: Mice, Knock-out, Knockout Mice, Knock-out Mice 
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology… (More)

Topic mentions per year

Topic mentions per year

1981-2018
01000200019812018

Papers overview

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Review
2016
Review
2016
Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions… (More)
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Highly Cited
2003
Highly Cited
2003
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound… (More)
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Highly Cited
2001
Highly Cited
2001
We previously reported the disruption of the murine gene encoding the transcription factor USF2 and its consequences on glucose… (More)
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Highly Cited
2000
Highly Cited
2000
Estrogen regulates the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve… (More)
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Highly Cited
1999
Highly Cited
1999
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to… (More)
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Highly Cited
1999
Highly Cited
1999
MyD88 is a general adaptor protein that plays an important role in the Toll/IL-1 receptor family signalings. Recently, Toll-like… (More)
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Highly Cited
1997
Highly Cited
1997
Fragile X syndrome arises from blocked expression of the fragile X mental retardation protein (FMRP). Golgi-impregnated mature… (More)
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Highly Cited
1996
Highly Cited
1996
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… (More)
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Highly Cited
1996
Highly Cited
1996
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by… (More)
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Highly Cited
1993
Highly Cited
1993
We employed homologous recombination in embryonic stem cells to produce mice lacking functional LDL receptor genes. Homozygous… (More)
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