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Metyrapone

Known as: Metirapona, 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, Metyraponum 
A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol… 
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (6)

2-bromophenylmetyrapone2-hydroxyphenylmetyrapone2-methoxyphenylmetyraponeMetopirone

Broader (4)

ACTH inhibitorAntimetabolitesEnzyme InhibitorsPyridines
Cushing SyndromeIn BloodMETYRAPONE TARTRATEMetyrapone 250 MG Oral Capsule [Metopirone]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients.
BACKGROUND Cushing's syndrome (CS) is a severe condition with excess mortality and significant morbidity necessitating control of… 
Highly Cited
2011
Highly Cited
2011
Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome.
CONTEXT Mitotane is highly effective in the long-term management of Cushing's syndrome but has a slow onset of action. Mitotane… 
Highly Cited
2004
Highly Cited
2004
Genomic and non-genomic effects of glucocorticoids on aggressive behavior in male rats
Review
1997
Review
1997
A neuroendocrine role in cocaine reinforcement
Highly Cited
1995
Highly Cited
1995
Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver.
Highly Cited
1992
Highly Cited
1992
Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system.
Highly Cited
1985
Highly Cited
1985
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Highly Cited
1985
Highly Cited
1985
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.
Highly Cited
1984
Highly Cited
1984
Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes.
Highly Cited
1968
Highly Cited
1968
Radioimmunoassay of ACTH in plasma.
Techniques are described in detail for a radioimmunoassay of plasma adrenocorticotropin (ACTH) that is capable of detecting… 
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