Metyrapone

Known as: Metirapona, 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, Metyraponum 
A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
RATIONALE Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol… (More)
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Highly Cited
2004
Highly Cited
2004
Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and xenobiotics, such as pollutants, environmental… (More)
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2004
2004
This is the first study of the action of metyrapone on Pavlovian extinction. Pavlovian acquisition memory can be impaired when 50… (More)
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Highly Cited
2002
Highly Cited
2002
In the present article, we report on two studies performed in young human populations which tested the cognitive impact of… (More)
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Highly Cited
1997
Highly Cited
1997
We showed previously that brief footshock stress and priming injections of heroin reinstate heroin-seeking after prolonged drug… (More)
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Highly Cited
1996
Highly Cited
1996
Increasing evidence indicates that glucocorticoids (GCs), produced in response to physical/emotional stressors, can exacerbate… (More)
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1995
1995
Eight inpatients with Major Depression were treated with metyrapone and hydrocortisone in a balanced order placebo-controlled… (More)
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Highly Cited
1991
Highly Cited
1991
OBJECTIVE To analyse the clinical and biochemical effects of metyrapone in the treatment of Cushing's syndrome. DESIGN An… (More)
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Highly Cited
1985
Highly Cited
1985
The individual members of a homologous series of phenoxazone ethers related to ethoxyresorufin were O-dealkylated, and the parent… (More)
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1977
1977
Metyrapone was used in the long-term management of 13 patients with pituitary-dependent bilateral adrenal hyperplasia (Cushing's… (More)
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