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Metyrapone

Known as: Metirapona, 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, Metyraponum 
A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol… 
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (6)

2-bromophenylmetyrapone2-hydroxyphenylmetyrapone2-methoxyphenylmetyraponeMetopirone

Broader (4)

ACTH inhibitorAntimetabolitesEnzyme InhibitorsPyridines
Cushing SyndromeIn BloodMETYRAPONE TARTRATEMetyrapone 250 MG Oral Capsule [Metopirone]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1992
Highly Cited
1992
Neuro-hormonal host defence in endotoxin shock
Highly Cited
1988
Highly Cited
1988
Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with heme-proteins by electron spin resonance spectroscopy.
Highly Cited
1982
Highly Cited
1982
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.
Highly Cited
1979
Highly Cited
1979
Induction and characterization of hemoprotein(s) P-450 and monooxygenation in rainbow trout (Salmo gairdneri).
Highly Cited
1978
Highly Cited
1978
Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver.
Highly Cited
1975
Highly Cited
1975
Tetrahydrofurane - an inhibitor for ethanol-induced liver microsomal cytochrome P450.
Highly Cited
1975
Highly Cited
1975
Heterogeneity of liver microsomal cytochrome P-450: the spectral characterization of reactants with reduced cytochrome P-450.
Highly Cited
1973
Highly Cited
1973
Cushing's syndrome. An evaluation of the clinical usefulness of urinary free cortisol and other urinary steroid measurements in diagnosis.
Highly Cited
1973
Highly Cited
1973
Benzene metabolism in mouse liver microsomes.
Highly Cited
1961
Highly Cited
1961
Clinical use of a new diagnostic agent, methopyrapone (SU-4885), in pituitary and adrenocortical disorders.
Excerpt Disorders involving the adrenocortical secretion of cortisol have become more precisely characterized within recent years… 
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