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Metabolic Biotransformation
Known as:
Biotransformation
, Biotransformation (Metabolism)
, biotransformations
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the…
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National Institutes of Health
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Related topics
Related topics
10 relations
Biodegradation
Bioremediation
Environmental Pollution
Metabolic Detoxication, Drug
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Narrower (1)
Catabolism
Broader (1)
Metabolism
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Plasma Concentrations of Risperidone and 9-Hydroxyrisperidone During Combined Treatment With Paroxetine
E. Spina
,
A. Avenoso
,
G. Facciolá
,
M. G. Scordo
,
M. Ancione
,
A. Madia
Therapeutic Drug Monitoring
2001
Corpus ID: 41937480
The effects of paroxetine on steady-state plasma concentrations of risperidone and its active metabolite 9-hydroxyrisperidone (9…
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Highly Cited
1998
Highly Cited
1998
Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones.
U. Bornscheuer
,
J. Altenbuchner
,
H. Meyer
Biotechnology and Bioengineering
1998
Corpus ID: 28589425
The directed evolution of an esterase from Pseudomonas fluorescens using the mutator strain Epicurian coli XL1-Red was…
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Highly Cited
1992
Highly Cited
1992
Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa.
W. Peters
,
Cindy E.W. Boon
,
H. Roelofs
,
T. Wobbes
,
F. Nagengast
,
P. Kremers
Gastroenterology
1992
Corpus ID: 22716343
Highly Cited
1986
Highly Cited
1986
Damage to biological tissues induced by radical initiator 2,2'-azobis(2-amidinopropane) dihydrochloride and its inhibition by chain-breaking antioxidants.
K. Terao
,
E. Niki
Journal of Free Radicals in Biology & Medicine
1986
Corpus ID: 37548863
Highly Cited
1984
Highly Cited
1984
Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans.
W. Dekant
,
Manfred Metzler
,
D. Henschler
Biochemical Pharmacology
1984
Corpus ID: 43187385
Highly Cited
1983
Highly Cited
1983
Turnover and functions of glutathione studied with isolated hepatic and renal cells.
S. Orrenius
,
K. Ormstad
,
H. Thor
,
S. Jewell
Federation proceedings
1983
Corpus ID: 41418844
Suspensions of freshly isolated rat hepatocytes and renal tubular cells contain high levels of reduced glutathione (GSH), which…
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Review
1979
Review
1979
Influence of cigarette smoking on drug metabolism in man.
William J. Jusko
Drug metabolism reviews (Softcover ed.)
1979
Corpus ID: 20609628
The pervasiveness of tobacco use in our society and the frequency of altered disposition of many common therapeutic and…
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Highly Cited
1979
Highly Cited
1979
Metabolism of theophylline to caffeine in premature newborn infants.
C. Bory
,
P. Baltassat
,
M. Porthault
,
M. Bethenod
,
A. Frédérich
,
J. Aranda
Jornal de Pediatria
1979
Corpus ID: 21164442
Highly Cited
1977
Highly Cited
1977
A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): utilization with a variety of mutagenic…
J. O'neill
,
D. B. Couch
,
R. Machanoff
,
J. Sebastian
,
P. Brimer
,
Abraham W. Hsie
Mutation research
1977
Corpus ID: 41222005
Highly Cited
1972
Highly Cited
1972
Metabolism of steroid and amino acid moieties of conjugated bile acids in man. I. Cholylglycine.
G. Hepner
,
A. Hofmann
,
P. J. Thomas
Journal of Clinical Investigation
1972
Corpus ID: 23667493
Cholyl-2,4-(3)H-glycine-1-(14)C was administered orally to eight healthy subjects with indwelling nasoduodenal tubes. The…
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