FAQ

Metabolic Biotransformation

Known as: Biotransformation, Biotransformation (Metabolism), biotransformations 
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Related topics

Related topics

9 relations
BiodegradationBioremediationEnvironmental PollutionMetabolic Detoxication, Drug
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Narrower (1)

Catabolism

Broader (1)

Metabolism

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Metabolic Biotransformation
physiological aspects
Catabolism
Metabolism
Metabolic Detoxication, Drug
Biodegradation

Papers overview

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Highly Cited
2005
Highly Cited
2005
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
PURPOSE Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect… (More)
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Highly Cited
2004
Highly Cited
2004
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.
We performed comprehensive kinetic, inhibition, and correlation analyses in human liver microsomes and experiments in expressed… (More)
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Highly Cited
2003
Highly Cited
2003
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.
Cultures of primary hepatocytes and hepatoma cell line HepG2 are frequently used in in vitro models for human biotransformation… (More)
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Highly Cited
2002
Highly Cited
2002
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The… (More)
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Highly Cited
2000
Highly Cited
2000
Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation.
A potential new metabolic pathway of melatonin biotransformation is described in this investigation. Melatonin was found to… (More)
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Highly Cited
1999
Highly Cited
1999
Biotransformation of curcumin through reduction and glucuronidation in mice.
Curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. In this study, we… (More)
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Highly Cited
1996
Highly Cited
1996
Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans.
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… (More)
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Highly Cited
1994
Highly Cited
1994
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… (More)
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Highly Cited
1994
Highly Cited
1994
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.
The principal taxol biotransformation reaction of humans and of human hepatic in vitro preparations is 6 alpha-hydroxylation of… (More)
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Highly Cited
1992
Highly Cited
1992
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
Six human cytochrome P450s expressed in HepG2 cells using vaccinia virus cDNA-directed expression, were used to study the… (More)
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