Metabolic Biotransformation

Known as: Biotransformation, Biotransformation (Metabolism), biotransformations 
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Papers overview

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Highly Cited
2005
Highly Cited
2005
PURPOSE Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect… (More)
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Highly Cited
2004
Highly Cited
2004
We performed comprehensive kinetic, inhibition, and correlation analyses in human liver microsomes and experiments in expressed… (More)
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Highly Cited
2003
Highly Cited
2003
Cultures of primary hepatocytes and hepatoma cell line HepG2 are frequently used in in vitro models for human biotransformation… (More)
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Highly Cited
2002
Highly Cited
2002
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The… (More)
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Highly Cited
2000
Highly Cited
2000
A potential new metabolic pathway of melatonin biotransformation is described in this investigation. Melatonin was found to… (More)
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Highly Cited
1999
Highly Cited
1999
Curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. In this study, we… (More)
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Highly Cited
1996
Highly Cited
1996
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… (More)
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Highly Cited
1994
Highly Cited
1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… (More)
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Highly Cited
1994
Highly Cited
1994
The principal taxol biotransformation reaction of humans and of human hepatic in vitro preparations is 6 alpha-hydroxylation of… (More)
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Highly Cited
1992
Highly Cited
1992
Six human cytochrome P450s expressed in HepG2 cells using vaccinia virus cDNA-directed expression, were used to study the… (More)
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