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The metabolic fate of dietary polyphenols in humans.
- A. Rechner, Gunter K. Kuhnle, P. Bremner, G. Hubbard, K. Moore, C. Rice-evans
- Chemistry, MedicineFree radical biology & medicine
- 15 July 2002
The results show that the majority of the in vivo forms derive from cleavage products of the action of colonic bacterial enzymes and subsequent metabolism in the liver, and suggest that consideration should be given to the cleavage Products as having a putative role as physiologically relevant bioactive components in vivo.
Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites.
The antibacterial activity-guided fractionation of the dichloromethane extract of leaves of Helichrysum pedunculatum resulted in the isolation of linoleic and oleic acids, and a synergistic effect between the two fatty acids was observed against Staphylococcus aureus and Micrococcus kristinae.
Natural products as targeted modulators of the nuclear factor‐KB pathway
This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B, and a large number of compounds currently known as NF‐κB modulators are assessed.
Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators.
This project has identified a series of species with an activity profile which merits further phytochemical-pharmacological investigation and a multitarget, cell-based approach focusing on the pro-inflammatory signaling cascade and especially the NF-kappaB (NF-kappB) pathway.
NF-κ B Modulators from Valeriana officinalis
Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has…
Molecular identification of Hypericum perforatum by PCR amplification of the ITS and 5.8S rDNA region.
- C. Howard, P. Bremner, M. Fowler, Belinda Isodo, N. Scott, A. Slater
- Biology, MedicinePlanta medica
- 4 March 2009
The nuclear ribosomal internal transcribed spacer (ITS) sequences of eight Hypericum species were used to design H. perforatum-specific PCR primers by identification of short "microcode" sequences characteristic of the target species, presenting a novel use for DNA barcoding data.
Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.
- A. Macho, M. Blanco-Molina, +5 authors E. Muñoz
- Biology, MedicineBiochemical pharmacology
- 1 September 2004
The evaluation of ferutinin analogs in calcium mobilization and apoptosis assays showed strict structure-activity relationships, with p-hydroxylation of the benzoyl moiety being requested for activity.
In Vitro evaluation of effects of two ghanaian plants relevant to wound healing
- A. Mensah, P. Houghton, R. Dickson, T. C. Fleischer, M. Heinrich, P. Bremner
- Biology, MedicinePhytotherapy research : PTR
- 1 November 2006
The antioxidant activities and antimicrobial activities of Commelina diffusa herb and Spathodea campanulata bark suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.
Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx.
Six biflavonoid and related compounds were isolated from the ethanolic extract of Ochna macrocalyx bark and one is a new compound, the isoflavanone dimer dehydroxyhexaspermone C, which is presented here for the first time.
Cytotoxic activity of a podophyllotoxin-like lignan from Linum tauricum Willd.
It could be concluded that 4'-DM-6-Mptox necessitates further pharmacological and toxicological evaluation as a possible chemotherapeutic agent and due to its relatively high concentrations in the described plant source the possibility for its use as a precursor for the semisynthetic production of lignan-based drugs, could be considered.